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Structure of human Heat shock protein 90-alpha N-terminal domain (Hsp90-NTD) variant K112R in complex with cAMP

X-ray diffraction
1.72Å resolution
PDB entry 6gqu coloured by chain, front view.
PDB entry 6gqu coloured by chain, side view.
PDB entry 6gqu coloured by chain, top view.
Source organism: Homo sapiens
Assembly composition:
monomeric (preferred)
Entry contents: 1 distinct polypeptide molecule

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Assemblies

Assembly 1 (preferred)
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Assembly Name: Heat shock protein HSP 90-alpha
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Multimeric state: monomeric
Accessible surface area: 12955.16 Å2
Buried surface area: 605.25 Å2
Dissociation area: 302.62 Å2
Dissociation energy (ΔGdiss): -3.82 kcal/mol
Dissociation entropy (TΔSdiss): 4.17 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-139817

Macromolecules

Heat shock protein HSP 90-alpha
Chain: A
Length: 256 amino acids
Theoretical weight: 28.8 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: P07900 (Residues: 1-236; Coverage: 32%)
Gene names: HSP90A, HSP90AA1, HSPC1, HSPCA
Pfam: Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase
InterPro:
Heat shock protein HSP 90-alpha in PDB entry 6gqu, assembly 1, front view.
Heat shock protein HSP 90-alpha in PDB entry 6gqu, assembly 1, side view.
Heat shock protein HSP 90-alpha in PDB entry 6gqu, assembly 1, top view.
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