Structure analysis

E1 enzyme for ubiquitin like protein activation.

X-ray diffraction
2.7Å resolution
Source organism: Homo sapiens
Assembly composition:
homo dimer (preferred)
Entry contents: 1 distinct polypeptide molecule

Assemblies

Assembly 1
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Multimeric state: homo dimer
Accessible surface area: 21479.09 Å2
Buried surface area: 10006.29 Å2
Dissociation area: 3,253.86 Å2
Dissociation energy (ΔGdiss): 49.1 kcal/mol
Dissociation entropy (TΔSdiss): 14 kcal/mol
Symmetry number: 2
PDBe Complex ID: PDB-CPX-190465
Assembly 2
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Multimeric state: homo dimer
Accessible surface area: 21252.37 Å2
Buried surface area: 9422.76 Å2
Dissociation area: 3,202.65 Å2
Dissociation energy (ΔGdiss): 47.4 kcal/mol
Dissociation entropy (TΔSdiss): 13.98 kcal/mol
Symmetry number: 2
PDBe Complex ID: PDB-CPX-190465
Assembly 3
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Multimeric state: homo dimer
Accessible surface area: 21329.89 Å2
Buried surface area: 9343.81 Å2
Dissociation area: 3,084.8 Å2
Dissociation energy (ΔGdiss): 50.48 kcal/mol
Dissociation entropy (TΔSdiss): 13.95 kcal/mol
Symmetry number: 2
PDBe Complex ID: PDB-CPX-190465
Assembly 4
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Multimeric state: homo dimer
Accessible surface area: 20501.17 Å2
Buried surface area: 9417.36 Å2
Dissociation area: 3,167.46 Å2
Dissociation energy (ΔGdiss): 49.24 kcal/mol
Dissociation entropy (TΔSdiss): 13.96 kcal/mol
Symmetry number: 2
PDBe Complex ID: PDB-CPX-190465
Assembly 5
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Multimeric state: homo dimer
Accessible surface area: 21251.2 Å2
Buried surface area: 9609.45 Å2
Dissociation area: 3,210.48 Å2
Dissociation energy (ΔGdiss): 43.29 kcal/mol
Dissociation entropy (TΔSdiss): 13.99 kcal/mol
Symmetry number: 2
PDBe Complex ID: PDB-CPX-190465
Assembly 6 (preferred)
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Multimeric state: homo dimer
Accessible surface area: 21030.61 Å2
Buried surface area: 9423.77 Å2
Dissociation area: 3,054.27 Å2
Dissociation energy (ΔGdiss): 49.25 kcal/mol
Dissociation entropy (TΔSdiss): 13.94 kcal/mol
Symmetry number: 2
PDBe Complex ID: PDB-CPX-190465
Assembly 7
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Multimeric state: homo dimer
Accessible surface area: 21346.29 Å2
Buried surface area: 8786.94 Å2
Dissociation area: 3,001.1 Å2
Dissociation energy (ΔGdiss): 51.92 kcal/mol
Dissociation entropy (TΔSdiss): 13.93 kcal/mol
Symmetry number: 2
PDBe Complex ID: PDB-CPX-190465
Assembly 8
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Multimeric state: homo dimer
Accessible surface area: 21221.4 Å2
Buried surface area: 9976.34 Å2
Dissociation area: 3,163.34 Å2
Dissociation energy (ΔGdiss): 48.85 kcal/mol
Dissociation entropy (TΔSdiss): 13.97 kcal/mol
Symmetry number: 2
PDBe Complex ID: PDB-CPX-190465

Macromolecules

Chains: A, B, C, D, E, F, G, H, I, J, K, L, M, N, O, P
Length: 300 amino acids
Theoretical weight: 33.28 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: Q9GZZ9 (Residues: 36-335; Coverage: 74%)
Gene names: UBA5, UBE1DC1
Pfam: ThiF family
InterPro:

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