Function and Biology

Crystal structure of the Protease 1 (E29A,E60A,E80A) from Pyrococcus horikoshii co-crystallized with Tb-Xo4.

Source organism: Pyrococcus horikoshii OT3
Biochemical function: protein deglycase activity
Biological process: proteolysis
Cellular component: cytoplasm

EC 3.5.1.124: Protein deglycase

Reaction catalysed:
An N(6)-(1-hydroxy-2-oxopropyl)-[protein]-L-lysine + H(2)O = a [protein]-L-lysine + lactate
Systematic name:
A [protein]-L-amino acid-1-hydroxypropan-2-one hydrolase ((R)-lactate-forming)
Alternative Name(s):
  • DJ-1 protein
  • Glyoxylase III
  • PARK7 (gene name)
  • YajL (gene name)
  • YhbO (gene name)

GO terms

Biochemical function:
Biological process:
Cellular component:

Sequence family

Pfam Protein family (Pfam)
PF01965
Domain description: DJ-1/PfpI family
Occurring in:
  1. Deglycase PH1704
The deposited structure of PDB entry 6hf6 contains 3 copies of Pfam domain PF01965 (DJ-1/PfpI family) in Deglycase PH1704. Showing 1 copy in chain A.

InterPro InterPro annotations
IPR029062
Domain description: Class I glutamine amidotransferase-like
Occurring in:
  1. Deglycase PH1704
IPR006286
Domain description: Deglycase PfpI-like
Occurring in:
  1. Deglycase PH1704
IPR002818
Domain description: DJ-1/PfpI
Occurring in:
  1. Deglycase PH1704