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Protein crystal structure determination with the crystallophore, a nucleating and phasing agent.

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Engilberge S, Wagner T, Santoni G, Breyton C, Shima S, Franzetti B, Riobé F, Maury O, Girard E
OpenAccess logo J Appl Crystallogr 52 722-731 (2019)
Related entries: 6hf7, 6hk1

Cited: 10 times
EuropePMC logo PMID: 31396026

Abstract

Obtaining crystals and solving the phase problem remain major hurdles encountered by bio-crystallographers in their race to obtain new high-quality structures. Both issues can be overcome by the crystallophore, Tb-Xo4, a lanthanide-based molecular complex with unique nucleating and phasing properties. This article presents examples of new crystallization conditions induced by the presence of Tb-Xo4. These new crystalline forms bypass crystal defects often encountered by crystallographers, such as low-resolution diffracting samples or crystals with twinning. Thanks to Tb-Xo4's high phasing power, the structure determination process is greatly facilitated and can be extended to serial crystallography approaches.

Articles - 6hf6 mentioned but not cited (2)

  1. A simple and versatile microfluidic device for efficient biomacromolecule crystallization and structural analysis by serial crystallography. de Wijn R, Hennig O, Roche J, Engilberge S, Rollet K, Fernandez-Millan P, Brillet K, Betat H, Mörl M, Roussel A, Girard E, Mueller-Dieckmann C, Fox GC, Olieric V, Gavira JA, Lorber B, Sauter C. IUCrJ 6 454-464 (2019)
  2. Protein crystal structure determination with the crystallophore, a nucleating and phasing agent. Engilberge S, Wagner T, Santoni G, Breyton C, Shima S, Franzetti B, Riobé F, Maury O, Girard E. J Appl Crystallogr 52 722-731 (2019)


Reviews citing this publication (1)

  1. NMR Spectroscopy of supramolecular chemistry on protein surfaces. Bayer P, Matena A, Beuck C. Beilstein J Org Chem 16 2505-2522 (2020)

Articles citing this publication (7)



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