› 6hjp

Electron Microscopy
3.3Å resolution

Structure of Influenza Hemagglutinin ectodomain (A/duck/Alberta/35/76) in complex with FISW84 Fab Fragment

Released:
DOI: 10.2210/pdb6hjp/pdb
PDB entry 6hjp coloured by chain, front view.
PDB entry 6hjp coloured by chain, side view.
PDB entry 6hjp coloured by chain, top view.
Source organisms:
Primary publication:
Influenza hemagglutinin membrane anchor.
Benton DJ, Nans A, Calder LJ, Turner J, Neu U, Lin YP, Ketelaars E, Kallewaard NL, Corti D, Lanzavecchia A, Gamblin SJ, Rosenthal PB, Skehel JJ
OpenAccess logo Proc Natl Acad Sci U S A 115 10112-10117 (2018)
PMID: 30224494
Related structures: EMD-0235

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
hetero dodecamer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-210912 (preferred)
Entry contents:
4 distinct polypeptide molecules
Macromolecules (8 distinct):
Hemagglutinin HA1 chain Chains: A, C, E
Molecule details ›
Chains: A, C, E
Length: 324 amino acids
Theoretical weight: 35.68 KDa
Source organism: Influenza A virus (A/mallard/Alberta/35/1976(H1N1))
UniProt:
  • Canonical: P26562 (Residues: 18-341; Coverage: 59%)
Gene name: HA
Sequence domains: Haemagglutinin
Structure domains:
Hemagglutinin HA2 chain Chains: B, D, F
Molecule details ›
Chains: B, D, F
Length: 174 amino acids
Theoretical weight: 19.95 KDa
Source organism: Influenza A virus (A/mallard/Alberta/35/1976(H1N1))
UniProt:
  • Canonical: P26562 (Residues: 345-518; Coverage: 32%)
Gene name: HA
Sequence domains: Haemagglutinin
Structure domains: Hemagglutinin Ectodomain; Chain B
Heavy chain of FISW84 Fab Fragment Chains: G, I, K
Molecule details ›
Chains: G, I, K
Length: 216 amino acids
Theoretical weight: 22.93 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
Light chain of FISW84 Fab Fragment Chains: H, J, L
Molecule details ›
Chains: H, J, L
Length: 214 amino acids
Theoretical weight: 23.28 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
Structure domains: Immunoglobulins

Ligands and Environments

Carbohydrate polymer : NEW Components: NAG
Carbohydrate polymer
Carbohydrate polymer : NEW Components: NAG, BMA, FUC
Carbohydrate polymer
Carbohydrate polymer : NEW Components: NAG, BMA, MAN
Carbohydrate polymer
Carbohydrate polymer : NEW Components: NAG, BMA
Carbohydrate polymer
1 bound ligand:
Ligand UPL 3 x UPL
No modified residues

Experiments and Validation Details

Entry percentile scores
Resolution: 3.3Å
Relevant EMDB volumes: EMD-0235
Expression system: Homo sapiens

Quick links

Citations

14 review citations

Influenza Hemagglutinin Structures and Antibody Recognition.
Wu et al. (2020)
13 more

2 mentions without citation

Influenza hemagglutinin membrane anchor.
Benton et al. (2018)
1 more