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Cryo-EM structure of the KdpFABC complex in an E1 outward-facing state (state 1)

Electron Microscopy
3.7Å resolution
PDB entry 6hra coloured by chain, front view.
PDB entry 6hra coloured by chain, side view.
PDB entry 6hra coloured by chain, top view.
Source organism: Escherichia coli K-12
Assembly composition:
hetero tetramer (preferred)
Entry contents: 4 distinct polypeptide molecules

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Assemblies

Assembly 1 (preferred)
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Assembly Name: KdpFABC potassium import complex
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Multimeric state: hetero tetramer
Accessible surface area: 53523.55 Å2
Buried surface area: 15646.76 Å2
Dissociation area: 994.33 Å2
Dissociation energy (ΔGdiss): 16.33 kcal/mol
Dissociation entropy (TΔSdiss): 9.57 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-137301
Complex Portal ID: CPX-3564

Macromolecules

Potassium-transporting ATPase potassium-binding subunit
Chain: A
Length: 557 amino acids
Theoretical weight: 59.22 KDa
Source organism: Escherichia coli K-12
Expression system: Escherichia coli
UniProt:
  • Canonical: P03959 (Residues: 1-557; Coverage: 100%)
Gene names: JW0686, b0698, kdpA
Pfam: Potassium-transporting ATPase A subunit
InterPro: Potassium-transporting ATPase A chain
Potassium-transporting ATPase potassium-binding subunit in PDB entry 6hra, assembly 1, front view.
Potassium-transporting ATPase potassium-binding subunit in PDB entry 6hra, assembly 1, side view.
Potassium-transporting ATPase potassium-binding subunit in PDB entry 6hra, assembly 1, top view.
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Potassium-transporting ATPase KdpC subunit
Chain: C
Length: 190 amino acids
Theoretical weight: 20.28 KDa
Source organism: Escherichia coli K-12
Expression system: Escherichia coli
UniProt:
  • Canonical: P03961 (Residues: 1-190; Coverage: 100%)
Gene names: JW0684, b0696, kdpC
Pfam: K+-transporting ATPase, c chain
InterPro: Potassium-transporting ATPase C chain
Potassium-transporting ATPase KdpC subunit in PDB entry 6hra, assembly 1, front view.
Potassium-transporting ATPase KdpC subunit in PDB entry 6hra, assembly 1, side view.
Potassium-transporting ATPase KdpC subunit in PDB entry 6hra, assembly 1, top view.
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Potassium-transporting ATPase KdpF subunit
Chain: D
Length: 29 amino acids
Theoretical weight: 3.07 KDa
Source organism: Escherichia coli K-12
Expression system: Escherichia coli
UniProt:
  • Canonical: P36937 (Residues: 1-29; Coverage: 100%)
Gene names: JW0687, b4513, kdpF
Pfam: F subunit of K+-transporting ATPase (Potass_KdpF)
InterPro: K+ transporting P-type ATPase, F subunit
Potassium-transporting ATPase KdpF subunit in PDB entry 6hra, assembly 1, front view.
Potassium-transporting ATPase KdpF subunit in PDB entry 6hra, assembly 1, side view.
Potassium-transporting ATPase KdpF subunit in PDB entry 6hra, assembly 1, top view.
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Potassium-transporting ATPase ATP-binding subunit
Chain: B
Length: 682 amino acids
Theoretical weight: 72.35 KDa
Source organism: Escherichia coli K-12
Expression system: Escherichia coli
UniProt:
  • Canonical: P03960 (Residues: 1-682; Coverage: 100%)
Gene names: JW0685, b0697, kdpB
Pfam:
InterPro:
Potassium-transporting ATPase ATP-binding subunit in PDB entry 6hra, assembly 1, front view.
Potassium-transporting ATPase ATP-binding subunit in PDB entry 6hra, assembly 1, side view.
Potassium-transporting ATPase ATP-binding subunit in PDB entry 6hra, assembly 1, top view.
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