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THE GLIC PENTAMERIC LIGAND-GATED ION CHANNEL MUTANT Q193C

X-ray diffraction
2.58Å resolution
PDB entry 6hy5 coloured by chain, front view.
PDB entry 6hy5 coloured by chain, side view.
PDB entry 6hy5 coloured by chain, top view.
Source organism: Gloeobacter violaceus PCC 7421
Assembly composition:
homo pentamer (preferred)
Entry contents: 1 distinct polypeptide molecule

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Assemblies

Assembly 1 (preferred)
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Assembly Name: Proton-gated ion channel
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Multimeric state: homo pentamer
Accessible surface area: 62912.24 Å2
Buried surface area: 34510.51 Å2
Dissociation area: 97.64 Å2
Dissociation energy (ΔGdiss): 11.36 kcal/mol
Dissociation entropy (TΔSdiss): -1.1 kcal/mol
Symmetry number: 5
PDBe Complex ID: PDB-CPX-181806

Macromolecules

Proton-gated ion channel
Chains: A, B, C, D, E
Length: 311 amino acids
Theoretical weight: 35.6 KDa
Source organism: Gloeobacter violaceus PCC 7421
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: Q7NDN8 (Residues: 47-357; Coverage: 98%)
Gene names: glr4197, glvI
Pfam: Neurotransmitter-gated ion-channel ligand binding domain
InterPro:
CATH:
Proton-gated ion channel in PDB entry 6hy5, assembly 1, front view.
Proton-gated ion channel in PDB entry 6hy5, assembly 1, side view.
Proton-gated ion channel in PDB entry 6hy5, assembly 1, top view.
PDBe-KB: UniProt Coverage View: Q7NDN8  
131120406080100120140160180200220240260280300
 
100200300VSPPPPIADEPLTVNTGIYLIESYSLDDKAETFKVNAFLSLSWKDRRLAFDPVRSGVRVKTYEPEAIWIPEIRFVNVENARDADVVDISVSPDGTVQYLERFSARVLSPLDFRRYPFDSQTLHIYLIVRSVDTRNIVLAVDLEKVGKNDDVFLTGWDIESFTAVVKPANFALEDRLESKLDYQLRISRCYFSYIPNIILPMLFILFISWTAFWSTSYEANVTLVVSTLIAHIAFNILVETNLPKTPYMTYTGAIIFMIYLFYFVAVIEVTVQHYLKVESQPARAASITRASRIAFPVVFLLANIILAFLFF
UniProt
Q7NDN8
Chains
Domains
Secondary structure
Flexibility predictions
Ligand binding sites
Interaction interfaces
Sequence conservation
Molecule details ›

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