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Substrate/product bound Argininosuccinate lyase from Mycobacterium tuberculosis

Source organism: Mycobacterium tuberculosis H37Rv
Biochemical function: lyase activity
Biological process: arginine biosynthetic process via ornithine
Cellular component: peptidoglycan-based cell wall

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EC 4.3.2.1: Argininosuccinate lyase

Reaction catalysed:
2-(N(omega)-L-arginino)succinate = fumarate + L-arginine
Systematic name:
2-(N(omega)-L-arginino)succinate arginine-lyase (fumarate-forming)
Alternative Name(s):
  • 2-(omega-N-L-arginino)succinate arginine-lyase (fumarate-forming)
  • Arginine-succinate lyase
  • Argininosuccinic acid lyase
  • Arginosuccinase
  • N-(L-argininosuccinate) arginine-lyase
  • Omega-N-(L-arginino)succinate arginine-lyase

GO terms

Sequence families

Pfam Protein families (Pfam)
PF14698
Domain description: Argininosuccinate lyase C-terminal
Occurring in:
  1. Argininosuccinate lyase
The deposited structure of PDB entry 6ien contains 4 copies of Pfam domain PF14698 (Argininosuccinate lyase C-terminal) in Argininosuccinate lyase. Showing 1 copy in chain B.

PF00206
Domain description: Lyase
Occurring in:
  1. Argininosuccinate lyase
The deposited structure of PDB entry 6ien contains 4 copies of Pfam domain PF00206 (Lyase) in Argininosuccinate lyase. Showing 1 copy in chain B.

InterPro InterPro annotations
IPR000362
Domain description: Fumarate lyase family
Occurring in:
  1. Argininosuccinate lyase
IPR009049
Domain description: Argininosuccinate lyase
Occurring in:
  1. Argininosuccinate lyase
IPR029419
Domain description: Argininosuccinate lyase, C-terminal
Occurring in:
  1. Argininosuccinate lyase
IPR020557
Domain description: Fumarate lyase, conserved site
Occurring in:
  1. Argininosuccinate lyase
IPR024083
Domain description: Fumarase/histidase, N-terminal
Occurring in:
  1. Argininosuccinate lyase
IPR022761
Domain description: Fumarate lyase, N-terminal
Occurring in:
  1. Argininosuccinate lyase
IPR008948
Domain description: L-Aspartase-like
Occurring in:
  1. Argininosuccinate lyase

Structure domains

CATH CATH domains
1.20.200.10
Class: Mainly Alpha
Architecture: Up-down Bundle
Topology: Fumarase C; Chain A, domain 2
Homology: Fumarase/aspartase (Central domain)
Occurring in:
  1. Argininosuccinate lyase
The deposited structure of PDB entry 6ien contains 2 copies of CATH domain 1.20.200.10 (Fumarase C; Chain A, domain 2) in Argininosuccinate lyase. Showing 1 copy in chain B.
1.10.275.10
Class: Mainly Alpha
Architecture: Orthogonal Bundle
Topology: Fumarase C; Chain B, domain 1
Homology: Fumarase/aspartase (N-terminal domain)
Occurring in:
  1. Argininosuccinate lyase
The deposited structure of PDB entry 6ien contains 2 copies of CATH domain 1.10.275.10 (Fumarase C; Chain B, domain 1) in Argininosuccinate lyase. Showing 1 copy in chain B.
1.10.40.30
Class: Mainly Alpha
Architecture: Orthogonal Bundle
Topology: Ribonucleotide Reductase Protein R1; domain 1
Homology: Fumarase/aspartase (C-terminal domain)
Occurring in:
  1. Argininosuccinate lyase
The deposited structure of PDB entry 6ien contains 2 copies of CATH domain 1.10.40.30 (Ribonucleotide Reductase Protein R1; domain 1) in Argininosuccinate lyase. Showing 1 copy in chain B.

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