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Complex structure of Rab35 and its effector RUSC2

X-ray diffraction
2.4Å resolution
PDB entry 6if2 coloured by chain, front view.
PDB entry 6if2 coloured by chain, side view.
PDB entry 6if2 coloured by chain, top view.
Source organism: Homo sapiens
Assembly composition:
hetero dimer (preferred)
Entry contents: 2 distinct polypeptide molecules

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Assemblies

Assembly 1 (preferred)
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Assembly Name: AP-4 complex accessory subunit RUSC2 and Ras-related protein Rab-35
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Multimeric state: hetero dimer
Accessible surface area: 17253.56 Å2
Buried surface area: 2718.37 Å2
Dissociation area: 868.14 Å2
Dissociation energy (ΔGdiss): -0.75 kcal/mol
Dissociation entropy (TΔSdiss): 12.05 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-172247

Macromolecules

Ras-related protein Rab-35
Chain: B
Length: 186 amino acids
Theoretical weight: 21.1 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: Q15286 (Residues: 1-180; Coverage: 90%)
Gene names: RAB1C, RAB35, RAY
Pfam: Ras family
InterPro:
CATH: P-loop containing nucleotide triphosphate hydrolases
Ras-related protein Rab-35 in PDB entry 6if2, assembly 1, front view.
Ras-related protein Rab-35 in PDB entry 6if2, assembly 1, side view.
Ras-related protein Rab-35 in PDB entry 6if2, assembly 1, top view.
PDBe-KB: UniProt Coverage View: Q15286  
118620406080100120140160180
 
50100150
UniProt
Q15286
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Secondary structure
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Ligand binding sites
Interaction interfaces
Sequence conservation
Molecule details ›

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AP-4 complex accessory subunit RUSC2
Chain: A
Length: 205 amino acids
Theoretical weight: 22.76 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: Q8N2Y8 (Residues: 983-1181; Coverage: 13%)
Gene names: KIAA0375, RUSC2
Pfam: RUN domain
InterPro:
AP-4 complex accessory subunit RUSC2 in PDB entry 6if2, assembly 1, front view.
AP-4 complex accessory subunit RUSC2 in PDB entry 6if2, assembly 1, side view.
AP-4 complex accessory subunit RUSC2 in PDB entry 6if2, assembly 1, top view.
PDBe-KB: UniProt Coverage View: Q8N2Y8  
120520406080100120140160180200
 
50100150200
UniProt
Q8N2Y8
Chains
Domains
Secondary structure
Flexibility predictions
Interaction interfaces
Sequence conservation
Molecule details ›

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