EC 2.7.7.6: DNA-directed RNA polymerase
Reaction catalysed:
Nucleoside triphosphate + RNA(n) = diphosphate + RNA(n+1)
Systematic name:
Nucleoside-triphosphate:RNA nucleotidyltransferase (DNA-directed)
Alternative Name(s):
- C RNA formation factors
- C ribonucleic acid formation factors
- DNA-dependent RNA nucleotidyltransferase
- DNA-dependent RNA polymerase
- DNA-dependent ribonucleate nucleotidyltransferase
- Deoxyribonucleic acid-dependent ribonucleic acid polymerase
- RNA nucleotidyltransferase
- RNA nucleotidyltransferase (DNA-directed)
- RNA polymerase
- RNA polymerase I
- RNA polymerase II
- RNA polymerase III
- RNA transcriptase
- Ribonucleate nucleotidyltransferase
- Ribonucleate polymerase
- Ribonucleic acid nucleotidyltransferase
- Ribonucleic acid polymerase
- Ribonucleic acid transcriptase
- Ribonucleic polymerase
- Ribonucleic transcriptase
- Transcriptase
GO terms
Biochemical function:
Biological process:
Cellular component:
Sequence families
Protein families (Pfam)
PF03439
Domain description:
Early transcription elongation factor of RNA pol II, NGN section
Occurring in:
Occurring in:
InterPro annotations
IPR005570
Domain description:
DNA-directed RNA polymerases I, II, and III subunit RPABC3
Occurring in:
Occurring in:
IPR004823
Domain description:
TATA box binding protein associated factor (TAF), histone-like fold domain
Occurring in:
Occurring in:
IPR006591
Domain description:
RNA polymerase archaeal subunit P/eukaryotic subunit RPABC4
Occurring in:
Occurring in:
IPR029040
Domain description:
RNA polymerase subunit RPABC4/transcription elongation factor Spt4
Occurring in:
Occurring in:
IPR001529
Domain description:
DNA-directed RNA polymerase II subunit RPB9-like, zinc ribbon
Occurring in:
Occurring in:
IPR012164
Domain description:
DNA-directed RNA polymerase subunit/transcription factor S
Occurring in:
Occurring in:
IPR039747
Domain description:
DNA-directed RNA polymerases I, II, and III subunit RPABC4
Occurring in:
Occurring in:
IPR008193
Domain description:
DNA-directed RNA polymerase Rpb11, 13-16kDa subunit, conserved site
Occurring in:
Occurring in:
IPR009025
Domain description:
DNA-directed RNA polymerase, RBP11-like dimerisation domain
Occurring in:
Occurring in:
IPR019761
Domain description:
DNA-directed RNA polymerase M, 15kDa subunit, conserved site
Occurring in:
Occurring in:
IPR020708
Domain description:
DNA-directed RNA polymerase, 14-18kDa subunit, conserved site
Occurring in:
Occurring in:
IPR001514
Domain description:
DNA-directed RNA polymerase, 30-40kDa subunit, conserved site
Occurring in:
Occurring in:
IPR037033
Domain description:
DNA-directed RNA polymerase, subunit 2, hybrid-binding domain superfamily
Occurring in:
Occurring in:
IPR007120
Domain description:
DNA-directed RNA polymerase, subunit 2, hybrid-binding domain
Occurring in:
Occurring in:
Structure domains
CATH domains
1.10.20.10
Class:
Mainly Alpha
Architecture:
Orthogonal Bundle
Topology:
Histone, subunit A
Homology:
Histone, subunit A
Occurring in:
3.30.1360.10
Class:
Alpha Beta
Architecture:
2-Layer Sandwich
Topology:
Gyrase A; domain 2
Homology:
RNA polymerase, RBP11-like subunit
Occurring in:
2.40.50.140
Class:
Mainly Beta
Architecture:
Beta Barrel
Topology:
OB fold (Dihydrolipoamide Acetyltransferase, E2P)
Homology:
Nucleic acid-binding proteins
Occurring in:
1.20.1250.40
Class:
Mainly Alpha
Architecture:
Up-down Bundle
Topology:
Growth Hormone; Chain: A;
Homology:
Growth Hormone; Chain: A;
Occurring in:
3.30.40.210
Class:
Alpha Beta
Architecture:
2-Layer Sandwich
Topology:
Herpes Virus-1
Homology:
Herpes Virus-1
Occurring in:
2.20.25.190
Class:
Mainly Beta
Architecture:
Single Sheet
Topology:
N-terminal domain of TfIIb
Homology:
N-terminal domain of TfIIb
Occurring in:
2.20.28.30
Class:
Mainly Beta
Architecture:
Single Sheet
Topology:
Rubrerythrin, domain 2
Homology:
RNA polymerase ii, chain L
Occurring in:
1.10.10.60
Class:
Mainly Alpha
Architecture:
Orthogonal Bundle
Topology:
Arc Repressor Mutant, subunit A
Homology:
Homeodomain-like
Occurring in:
3.30.1490.120
Class:
Alpha Beta
Architecture:
2-Layer Sandwich
Topology:
Dna Ligase; domain 1
Homology:
RNA polymerase Rpb7-like, N-terminal domain
Occurring in:
3.90.940.10
Class:
Alpha Beta
Architecture:
Alpha-Beta Complex
Topology:
Eukaryotic RPB6 RNA polymerase subunit
Homology:
Eukaryotic RPB6 RNA polymerase subunit
Occurring in:
3.90.940.20
Class:
Alpha Beta
Architecture:
Alpha-Beta Complex
Topology:
Eukaryotic RPB6 RNA polymerase subunit
Homology:
RPB5-like RNA polymerase subunit
Occurring in:
3.40.1340.10
Class:
Alpha Beta
Architecture:
3-Layer(aba) Sandwich
Topology:
Dna-directed Rna Polymerases I, Ii, And Iii 27 Kd Polypeptide; Chain: A; domain 1
Homology:
RNA polymerase, Rpb5, N-terminal domain
Occurring in: