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Human SIRT3 Recognizing H3K4cr

X-ray diffraction
2.95Å resolution
PDB entry 6iso coloured by chain, front view.
PDB entry 6iso coloured by chain, side view.
PDB entry 6iso coloured by chain, top view.
Source organisms:
Assembly composition:
hetero dimer (preferred)
Entry contents: 2 distinct polypeptide molecules

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Assemblies

Assembly 1
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Assembly Name: NAD-dependent protein deacetylase sirtuin-3, mitochondrial and peptide
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Multimeric state: hetero dimer
Accessible surface area: 12532.33 Å2
Buried surface area: 1403.23 Å2
Dissociation area: 660.46 Å2
Dissociation energy (ΔGdiss): 2.9 kcal/mol
Dissociation entropy (TΔSdiss): 7.14 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-166904
Assembly 2 (preferred)
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Assembly Name: NAD-dependent protein deacetylase sirtuin-3, mitochondrial and peptide
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Multimeric state: hetero dimer
Accessible surface area: 12584.93 Å2
Buried surface area: 1481.2 Å2
Dissociation area: 564.58 Å2
Dissociation energy (ΔGdiss): 0.71 kcal/mol
Dissociation entropy (TΔSdiss): 7.05 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-166904
Assembly 3
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Assembly Name: NAD-dependent protein deacetylase sirtuin-3, mitochondrial and peptide
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Multimeric state: hetero dimer
Accessible surface area: 12377.08 Å2
Buried surface area: 1600.54 Å2
Dissociation area: 508.94 Å2
Dissociation energy (ΔGdiss): -0.35 kcal/mol
Dissociation entropy (TΔSdiss): 6.86 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-166904
Assembly 4
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Assembly Name: NAD-dependent protein deacetylase sirtuin-3, mitochondrial and peptide
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Multimeric state: hetero dimer
Accessible surface area: 12273.37 Å2
Buried surface area: 1784.72 Å2
Dissociation area: 666.75 Å2
Dissociation energy (ΔGdiss): 1.65 kcal/mol
Dissociation entropy (TΔSdiss): 7.07 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-166904
Assembly 5
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Assembly Name: NAD-dependent protein deacetylase sirtuin-3, mitochondrial and peptide
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Multimeric state: hetero dimer
Accessible surface area: 9643.94 Å2
Buried surface area: 1582.92 Å2
Dissociation area: 624.22 Å2
Dissociation energy (ΔGdiss): 1.47 kcal/mol
Dissociation entropy (TΔSdiss): 6.69 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-166904
Assembly 6
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Assembly Name: NAD-dependent protein deacetylase sirtuin-3, mitochondrial and peptide
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Multimeric state: hetero dimer
Accessible surface area: 12388.23 Å2
Buried surface area: 1120.8 Å2
Dissociation area: 431.56 Å2
Dissociation energy (ΔGdiss): -1.02 kcal/mol
Dissociation entropy (TΔSdiss): 6.75 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-166904

Macromolecules

NAD-dependent protein deacetylase sirtuin-3, mitochondrial
Chains: A, B, E, G, I, K
Length: 275 amino acids
Theoretical weight: 30.57 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli-Pichia pastoris shuttle vector pPpARG4
UniProt:
  • Canonical: Q9NTG7 (Residues: 121-394; Coverage: 69%)
Gene names: SIR2L3, SIRT3
Pfam: Sir2 family
InterPro:
CATH:
NAD-dependent protein deacetylase sirtuin-3, mitochondrial in PDB entry 6iso, assembly 2, front view.
NAD-dependent protein deacetylase sirtuin-3, mitochondrial in PDB entry 6iso, assembly 2, side view.
NAD-dependent protein deacetylase sirtuin-3, mitochondrial in PDB entry 6iso, assembly 2, top view.
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ARG-THR-LYS-GLN-THR-ALA-ARG
Chains: C, D, F, H, J, L
Length: 7 amino acids
Theoretical weight: 863 Da
Source organism: synthetic construct
Expression system: Not provided
ARG-THR-LYS-GLN-THR-ALA-ARG in PDB entry 6iso, assembly 2, front view.
ARG-THR-LYS-GLN-THR-ALA-ARG in PDB entry 6iso, assembly 2, side view.
ARG-THR-LYS-GLN-THR-ALA-ARG in PDB entry 6iso, assembly 2, top view.
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