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Complex structure of Axin-DIX and Dvl2-DIX

X-ray diffraction
3.09Å resolution
PDB entry 6jck coloured by chain, front view.
PDB entry 6jck coloured by chain, side view.
PDB entry 6jck coloured by chain, top view.
Source organism: Homo sapiens
Assembly composition:
hetero dimer (preferred)
Entry contents: 2 distinct polypeptide molecules

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Assemblies

Assembly 1 (preferred)
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Assembly Name: Segment polarity protein dishevelled homolog DVL-2 and Axin-1
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Multimeric state: hetero dimer
Accessible surface area: 8869.83 Å2
Buried surface area: 1232.11 Å2
Dissociation area: 616.05 Å2
Dissociation energy (ΔGdiss): -4.83 kcal/mol
Dissociation entropy (TΔSdiss): 10.03 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-127033

Macromolecules

Axin-1
Chain: A
Length: 82 amino acids
Theoretical weight: 9.47 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: O15169 (Residues: 781-862; Coverage: 10%)
Gene names: AXIN, AXIN1
Pfam: DIX domain
InterPro:
Axin-1 in PDB entry 6jck, assembly 1, front view.
Axin-1 in PDB entry 6jck, assembly 1, side view.
Axin-1 in PDB entry 6jck, assembly 1, top view.
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Segment polarity protein dishevelled homolog DVL-2
Chain: B
Length: 82 amino acids
Theoretical weight: 9.22 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: O14641 (Residues: 12-93; Coverage: 11%)
Gene name: DVL2
Pfam: DIX domain
InterPro:
Segment polarity protein dishevelled homolog DVL-2 in PDB entry 6jck, assembly 1, front view.
Segment polarity protein dishevelled homolog DVL-2 in PDB entry 6jck, assembly 1, side view.
Segment polarity protein dishevelled homolog DVL-2 in PDB entry 6jck, assembly 1, top view.
Molecule details ›

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