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Crystal structure of human DHODH in complex with inhibitor 1223

X-ray diffraction
1.781Å resolution
PDB entry 6jmd coloured by chain, front view.
PDB entry 6jmd coloured by chain, side view.
PDB entry 6jmd coloured by chain, top view.
Source organism: Homo sapiens
Assembly composition:
monomeric (preferred)
Entry contents: 1 distinct polypeptide molecule

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Assemblies

Assembly 1 (preferred)
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Assembly Name: Dihydroorotate dehydrogenase (quinone), mitochondrial
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Multimeric state: monomeric
Accessible surface area: 14539.65 Å2
Buried surface area: 2273.28 Å2
Dissociation area: 211.24 Å2
Dissociation energy (ΔGdiss): -7.09 kcal/mol
Dissociation entropy (TΔSdiss): 3.87 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-169672

Macromolecules

Dihydroorotate dehydrogenase (quinone), mitochondrial
Chain: A
Length: 366 amino acids
Theoretical weight: 39.73 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: Q02127 (Residues: 30-395; Coverage: 93%)
Gene name: DHODH
Pfam: Dihydroorotate dehydrogenase
InterPro:
Dihydroorotate dehydrogenase (quinone), mitochondrial in PDB entry 6jmd, assembly 1, front view.
Dihydroorotate dehydrogenase (quinone), mitochondrial in PDB entry 6jmd, assembly 1, side view.
Dihydroorotate dehydrogenase (quinone), mitochondrial in PDB entry 6jmd, assembly 1, top view.
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