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Structure of human soluble guanylate cyclase in the unliganded state

Electron Microscopy
4Å resolution
PDB entry 6jt0 coloured by chain, front view.
PDB entry 6jt0 coloured by chain, side view.
PDB entry 6jt0 coloured by chain, top view.
Source organism: Homo sapiens
Assembly composition:
hetero dimer (preferred)
Entry contents: 2 distinct polypeptide molecules

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Assemblies

Assembly 1 (preferred)
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Assembly Name: Soluble guanylate cyclase complex, SGCalpha1-SGCbeta1 variant
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Multimeric state: hetero dimer
Accessible surface area: 48966.6 Å2
Buried surface area: 11562.16 Å2
Dissociation area: 5,157.31 Å2
Dissociation energy (ΔGdiss): 74.59 kcal/mol
Dissociation entropy (TΔSdiss): 16.3 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-169668
Complex Portal ID: CPX-928

Macromolecules

Guanylate cyclase soluble subunit alpha-1
Chain: A
Length: 690 amino acids
Theoretical weight: 77.57 KDa
Source organism: Homo sapiens
Expression system: Spodoptera frugiperda
UniProt:
  • Canonical: Q02108 (Residues: 1-690; Coverage: 100%)
Gene names: GUC1A3, GUCSA3, GUCY1A1, GUCY1A3
Pfam:
InterPro:
Guanylate cyclase soluble subunit alpha-1 in PDB entry 6jt0, assembly 1, front view.
Guanylate cyclase soluble subunit alpha-1 in PDB entry 6jt0, assembly 1, side view.
Guanylate cyclase soluble subunit alpha-1 in PDB entry 6jt0, assembly 1, top view.
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Guanylate cyclase soluble subunit beta-1
Chain: B
Length: 619 amino acids
Theoretical weight: 70.6 KDa
Source organism: Homo sapiens
Expression system: Spodoptera frugiperda
UniProt:
  • Canonical: Q02153 (Residues: 1-619; Coverage: 100%)
Gene names: GUC1B3, GUCSB3, GUCY1B1, GUCY1B3
Pfam:
InterPro:
Guanylate cyclase soluble subunit beta-1 in PDB entry 6jt0, assembly 1, front view.
Guanylate cyclase soluble subunit beta-1 in PDB entry 6jt0, assembly 1, side view.
Guanylate cyclase soluble subunit beta-1 in PDB entry 6jt0, assembly 1, top view.
Molecule details ›

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