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Complex structure of LILRB4 and h128-3 antibody

X-ray diffraction
3.004Å resolution
PDB entry 6k7o coloured by chain, front view.
PDB entry 6k7o coloured by chain, side view.
PDB entry 6k7o coloured by chain, top view.
Source organism: Homo sapiens
Assembly composition:
hetero trimer (preferred)
Entry contents: 3 distinct polypeptide molecules

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Assemblies

Assembly 1
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Assembly Name: Leukocyte immunoglobulin-like receptor subfamily B member 4 and IG-heavy chain and IG-light kappa chain
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Multimeric state: hetero trimer
Accessible surface area: 23840.59 Å2
Buried surface area: 5493.19 Å2
Dissociation area: 708.61 Å2
Dissociation energy (ΔGdiss): -6.22 kcal/mol
Dissociation entropy (TΔSdiss): 11.62 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-212630
Assembly 2 (preferred)
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Assembly Name: Leukocyte immunoglobulin-like receptor subfamily B member 4 and IG-heavy chain and IG-light kappa chain
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Multimeric state: hetero trimer
Accessible surface area: 23482.78 Å2
Buried surface area: 5610.26 Å2
Dissociation area: 707.08 Å2
Dissociation energy (ΔGdiss): -6.03 kcal/mol
Dissociation entropy (TΔSdiss): 11.61 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-212630
Assembly 3
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Assembly Name: Leukocyte immunoglobulin-like receptor subfamily B member 4 and IG-heavy chain and IG-light kappa chain
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Multimeric state: hetero trimer
Accessible surface area: 23337.92 Å2
Buried surface area: 5527.15 Å2
Dissociation area: 691.77 Å2
Dissociation energy (ΔGdiss): -5.73 kcal/mol
Dissociation entropy (TΔSdiss): 11.61 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-212630
Assembly 4
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Assembly Name: Leukocyte immunoglobulin-like receptor subfamily B member 4 and IG-heavy chain and IG-light kappa chain
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Multimeric state: hetero trimer
Accessible surface area: 24113.36 Å2
Buried surface area: 5683.07 Å2
Dissociation area: 714.87 Å2
Dissociation energy (ΔGdiss): -6.86 kcal/mol
Dissociation entropy (TΔSdiss): 11.62 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-212630

Macromolecules

Leukocyte immunoglobulin-like receptor subfamily B member 4
Chains: A, P, Q, R
Length: 95 amino acids
Theoretical weight: 10.9 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21
UniProt:
  • Canonical: Q8NHJ6 (Residues: 24-118; Coverage: 22%)
Gene names: ILT3, LILRB4, LIR5
Pfam: Immunoglobulin domain
InterPro:
Leukocyte immunoglobulin-like receptor subfamily B member 4 in PDB entry 6k7o, assembly 2, front view.
Leukocyte immunoglobulin-like receptor subfamily B member 4 in PDB entry 6k7o, assembly 2, side view.
Leukocyte immunoglobulin-like receptor subfamily B member 4 in PDB entry 6k7o, assembly 2, top view.
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h128-3 Fab heavy chain
Chains: B, D, F, H
Length: 228 amino acids
Theoretical weight: 24.21 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
InterPro:
h128-3 Fab heavy chain in PDB entry 6k7o, assembly 2, front view.
h128-3 Fab heavy chain in PDB entry 6k7o, assembly 2, side view.
h128-3 Fab heavy chain in PDB entry 6k7o, assembly 2, top view.
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h128-3 Fab light chain
Chains: C, E, G, L
Length: 218 amino acids
Theoretical weight: 23.76 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
InterPro:
h128-3 Fab light chain in PDB entry 6k7o, assembly 2, front view.
h128-3 Fab light chain in PDB entry 6k7o, assembly 2, side view.
h128-3 Fab light chain in PDB entry 6k7o, assembly 2, top view.
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