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hASIC1a co-crystallized with Mamb-1

X-ray diffraction
3.24Å resolution
PDB entry 6l6i coloured by chain, front view.
PDB entry 6l6i coloured by chain, side view.
PDB entry 6l6i coloured by chain, top view.
Source organism: Homo sapiens
Assembly composition:
homo trimer (preferred)
Entry contents: 1 distinct polypeptide molecule

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Assemblies

Assembly 1 (preferred)
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Assembly Name: Acid-sensing ion channel 1
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Multimeric state: homo trimer
Accessible surface area: 58839.45 Å2
Buried surface area: 14984.42 Å2
Dissociation area: 7,218.25 Å2
Dissociation energy (ΔGdiss): 93.1 kcal/mol
Dissociation entropy (TΔSdiss): 31.81 kcal/mol
Symmetry number: 3
PDBe Complex ID: PDB-CPX-160250

Macromolecules

Acid-sensing ion channel 1
Chains: A, B, C
Length: 454 amino acids
Theoretical weight: 51.7 KDa
Source organism: Homo sapiens
Expression system: Spodoptera frugiperda
UniProt:
  • Canonical: P78348 (Residues: 25-464; Coverage: 83%)
Gene names: ACCN2, ASIC1, BNAC2
Pfam: Amiloride-sensitive sodium channel
InterPro:
Acid-sensing ion channel 1 in PDB entry 6l6i, assembly 1, front view.
Acid-sensing ion channel 1 in PDB entry 6l6i, assembly 1, side view.
Acid-sensing ion channel 1 in PDB entry 6l6i, assembly 1, top view.
PDBe-KB: UniProt Coverage View: P78348  
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