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Crystal structure of Cet1 from Trypanosoma cruzi in complex with tripolyphosphate, manganese and iodide ions.

Source organism: Trypanosoma cruzi strain CL Brener
Biochemical function: polynucleotide 5'-phosphatase activity
Biological process: not assigned
Cellular component: not assigned

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EC 3.6.1.74: mRNA 5'-phosphatase

Reaction catalysed:
A 5'-triphospho-[mRNA] + H(2)O = a 5'-diphospho-[mRNA] + phosphate
Systematic name:
5'-triphospho-mRNA 5'-phosphohydrolase
Alternative Name(s):
  • 5'-polynucleotidase
  • Polynucleotide 5'-phosphohydrolase
  • mRNA 5'-triphosphate monophosphatase

GO terms

Biochemical function:
Biological process:
  • not assigned
Cellular component:
  • not assigned

Sequence family

Pfam Protein family (Pfam)
PF02940
Domain description: mRNA capping enzyme, beta chain
Occurring in:
  1. mRNA 5'-phosphatase
The deposited structure of PDB entry 6l7v contains 1 copy of Pfam domain PF02940 (mRNA capping enzyme, beta chain) in mRNA 5'-phosphatase. Showing 1 copy in chain A.

InterPro InterPro annotations
IPR004206
Domain description: mRNA triphosphatase Cet1-like
Occurring in:
  1. mRNA 5'-phosphatase
IPR040343
Domain description: RNA 5'-triphosphatase Cet1/Ctl1
Occurring in:
  1. mRNA 5'-phosphatase
IPR033469
Domain description: CYTH-like domain superfamily
Occurring in:
  1. mRNA 5'-phosphatase
IPR037009
Domain description: mRNA triphosphatase Cet1-like superfamily
Occurring in:
  1. mRNA 5'-phosphatase

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