› 6lhv

Electron Microscopy
4.59Å resolution

Structure of FANCA and FANCG Complex

Released:
DOI: 10.2210/pdb6lhv/pdb
PDB entry 6lhv coloured by chain, front view.
PDB entry 6lhv coloured by chain, side view.
PDB entry 6lhv coloured by chain, top view.
Source organism: Xenopus laevis
Primary publication:
Structural basis of the fanconi anemia-associated mutations within the FANCA and FANCG complex.
Jeong E, Lee SG, Kim HS, Yang J, Shin J, Kim Y, Kim J, Schärer OD, Kim Y, Yeo JE, Kim HM, Cho Y
OpenAccess logo Nucleic Acids Res 48 3328-3342 (2020)
PMID: 32002546
Related structures: EMD-0900

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
hetero trimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-167018 (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
Fanconi anemia complementation group G Chain: C
Molecule details ›
Chain: C
Length: 400 amino acids
Theoretical weight: 34.06 KDa
Source organism: Xenopus laevis
Expression system: Trichoplusia ni
Fanconi anemia complementation group A Chains: A, B
Molecule details ›
Chains: A, B
Length: 800 amino acids
Theoretical weight: 68.1 KDa
Source organism: Xenopus laevis
Expression system: Trichoplusia ni

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
Resolution: 4.59Å
Relevant EMDB volumes: EMD-0900
Expression system: Trichoplusia ni

Quick links

Citations

1 review citation

Fanconi anemia pathway as a prospective target for cancer intervention.
Liu et al. (2020)
3 other articles

2 mentions without citation

Structural insight into FANCI-FANCD2 monoubiquitination.
Li et al. (2020)
1 more