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Cryo-EM structure of the CALHM chimeric construct (8-mer)

Electron Microscopy
3.4Å resolution
PDB entry 6lmw coloured by chain, front view.
PDB entry 6lmw coloured by chain, side view.
PDB entry 6lmw coloured by chain, top view.
Source organisms:
Assembly composition:
homo octamer (preferred)
Entry contents: 1 distinct polypeptide molecule

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Assemblies

Assembly 1 (preferred)
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Assembly Name: Calcium homeostasis modulator 1, Calcium homeostasis modulator protein 2
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Multimeric state: homo octamer
Accessible surface area: 74432.48 Å2
Buried surface area: 19218.68 Å2
Dissociation area: 9,609.34 Å2
Dissociation energy (ΔGdiss): 91.53 kcal/mol
Dissociation entropy (TΔSdiss): 95.5 kcal/mol
Symmetry number: 8
PDBe Complex ID: PDB-CPX-238608

Macromolecules

Calcium homeostasis modulator 1; Calcium homeostasis modulator protein 2
Chains: A, B, C, D, E, F, G, H
Length: 326 amino acids
Theoretical weight: 37.42 KDa
Source organisms: Expression system: Homo sapiens
UniProt:
  • Canonical: H2MCM1 (Residues: 1-209; Coverage: 60%)
  • Canonical: Q9HA72 (Residues: 213-323; Coverage: 34%)
    • nullnull
Gene names: CALHM1, CALHM2, FAM26B
Pfam: Calcium homeostasis modulator
InterPro: Calcium homeostasis modulator family
Calcium homeostasis modulator 1 in PDB entry 6lmw, assembly 1, front view.
Calcium homeostasis modulator 1 in PDB entry 6lmw, assembly 1, side view.
Calcium homeostasis modulator 1 in PDB entry 6lmw, assembly 1, top view.
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