› 6lmw

Electron Microscopy
3.4Å resolution

Cryo-EM structure of the CALHM chimeric construct (8-mer)

Released:
DOI: 10.2210/pdb6lmw/pdb
PDB entry 6lmw coloured by chain, front view.
PDB entry 6lmw coloured by chain, side view.
PDB entry 6lmw coloured by chain, top view.
Source organisms:
Primary publication:
Cryo-EM structures of calcium homeostasis modulator channels in diverse oligomeric assemblies.
Demura K, Kusakizako T, Shihoya W, Hiraizumi M, Nomura K, Shimada H, Yamashita K, Nishizawa T, Taruno A, Nureki O
OpenAccess logo Sci Adv 6 eaba8105 (2020)
PMID: 32832629
Related structures: EMD-0922

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domain:

Structure analysis Details

Assembly composition:
homo octamer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-238608 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Calcium homeostasis modulator 1; Calcium homeostasis modulator protein 2 Chains: A, B, C, D, E, F, G, H
Molecule details ›
Chains: A, B, C, D, E, F, G, H
Length: 326 amino acids
Theoretical weight: 37.42 KDa
Source organisms: Expression system: Homo sapiens
UniProt:
  • Canonical: H2MCM1 (Residues: 1-209; Coverage: 60%)
  • Canonical: Q9HA72 (Residues: 213-323; Coverage: 34%)
Gene names: CALHM1, CALHM2, FAM26B
Sequence domains: Calcium homeostasis modulator

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
Resolution: 3.4Å
Relevant EMDB volumes: EMD-0922
Expression system: Homo sapiens

Quick links

Citations

5 review citations

Taste transduction and channel synapses in taste buds.
Taruno et al. (2021)
4 more