Function and Biology

Crystal Structure of E447A Acyl-CoA Dehydrogenase FadE5 mutant from Mycobacteria smegmatis in complex with C22CoA

Source organism: Mycolicibacterium smegmatis
Biochemical function: medium-chain fatty acyl-CoA dehydrogenase activity
Biological process: fatty acid metabolic process
Cellular component: plasma membrane

EC 1.3.8.8: Long-chain-acyl-CoA dehydrogenase

Reaction catalysed:
Long-chain-acyl-CoA + electron-transfer flavoprotein = long-chain-2,3-dehydroacyl-CoA + reduced electron-transfer flavoprotein
Systematic name:
Long-chain-acyl-CoA:electron-transfer flavoprotein 2,3-oxidoreductase
Alternative Name(s):
  • ACADL (gene name)
  • Long-chain acyl-coenzyme A dehydrogenase
  • Long-chain-acyl-CoA:(acceptor) 2,3-oxidoreductase
  • Palmitoyl-CoA dehydrogenase
  • Palmitoyl-coenzyme A dehydrogenase

EC 1.3.8.7: Medium-chain acyl-CoA dehydrogenase

Reaction catalysed:
A medium-chain acyl-CoA + electron-transfer flavoprotein = a medium-chain trans-2,3-dehydroacyl-CoA + reduced electron-transfer flavoprotein
Systematic name:
Medium-chain acyl-CoA:electron-transfer flavoprotein 2,3-oxidoreductase
Alternative Name(s):
  • ACADM (gene name)
  • Acyl CoA dehydrogenase
  • Acyl coenzyme A dehydrogenase
  • Acyl dehydrogenase
  • Acyl-CoA:(acceptor) 2,3-oxidoreductase
  • Fatty acyl coenzyme A dehydrogenase
  • Fatty-acyl-CoA dehydrogenase
  • General acyl CoA dehydrogenase
  • Medium-chain acyl-coenzyme A dehydrogenase

EC 1.3.8.1: Short-chain acyl-CoA dehydrogenase

Reaction catalysed:
A short-chain acyl-CoA + electron-transfer flavoprotein = a short-chain trans-2,3-dehydroacyl-CoA + reduced electron-transfer flavoprotein
Systematic name:
Short-chain acyl-CoA:electron-transfer flavoprotein 2,3-oxidoreductase
Alternative Name(s):
  • 3-hydroxyacyl CoA reductase
  • ACADS (gene name)
  • Butanoyl-CoA dehydrogenase
  • Butanoyl-CoA:(acceptor) 2,3-oxidoreductase
  • Butyryl coenzyme A dehydrogenase
  • Butyryl dehydrogenase
  • Butyryl-CoA dehydrogenase
  • Enoyl-coenzyme A reductase
  • Ethylene reductase
  • Short-chain acyl CoA dehydrogenase
  • Short-chain acyl-coenzyme A dehydrogenase
  • Unsaturated acyl coenzyme A reductase
  • Unsaturated acyl-CoA reductase

Sequence families

Pfam Protein families (Pfam)
PF12806
Domain description: Acetyl-CoA dehydrogenase C-terminal like
Occurring in:
  1. Broad-specificity linear acyl-CoA dehydrogenase FadE5
The deposited structure of PDB entry 6lq8 contains 2 copies of Pfam domain PF12806 (Acetyl-CoA dehydrogenase C-terminal like) in Broad-specificity linear acyl-CoA dehydrogenase FadE5. Showing 1 copy in chain B.

PF00441
Domain description: Acyl-CoA dehydrogenase, C-terminal domain
Occurring in:
  1. Broad-specificity linear acyl-CoA dehydrogenase FadE5
The deposited structure of PDB entry 6lq8 contains 2 copies of Pfam domain PF00441 (Acyl-CoA dehydrogenase, C-terminal domain) in Broad-specificity linear acyl-CoA dehydrogenase FadE5. Showing 1 copy in chain B.

PF02770
Domain description: Acyl-CoA dehydrogenase, middle domain
Occurring in:
  1. Broad-specificity linear acyl-CoA dehydrogenase FadE5
The deposited structure of PDB entry 6lq8 contains 2 copies of Pfam domain PF02770 (Acyl-CoA dehydrogenase, middle domain) in Broad-specificity linear acyl-CoA dehydrogenase FadE5. Showing 1 copy in chain B.

PF12418
Domain description: Acyl-CoA dehydrogenase N terminal
Occurring in:
  1. Broad-specificity linear acyl-CoA dehydrogenase FadE5
The deposited structure of PDB entry 6lq8 contains 2 copies of Pfam domain PF12418 (Acyl-CoA dehydrogenase N terminal ) in Broad-specificity linear acyl-CoA dehydrogenase FadE5. Showing 1 copy in chain B.

InterPro InterPro annotations
IPR025878
Domain description: Acetyl-CoA dehydrogenase-like C-terminal domain
Occurring in:
  1. Broad-specificity linear acyl-CoA dehydrogenase FadE5
IPR036250
Domain description: Acyl-CoA dehydrogenase-like, C-terminal
Occurring in:
  1. Broad-specificity linear acyl-CoA dehydrogenase FadE5
IPR009075
Domain description: Acyl-CoA dehydrogenase/oxidase, C-terminal
Occurring in:
  1. Broad-specificity linear acyl-CoA dehydrogenase FadE5
IPR006091
Domain description: Acyl-CoA oxidase/dehydrogenase, middle domain
Occurring in:
  1. Broad-specificity linear acyl-CoA dehydrogenase FadE5
IPR009100
Domain description: Acyl-CoA dehydrogenase/oxidase, N-terminal and middle domain superfamily
Occurring in:
  1. Broad-specificity linear acyl-CoA dehydrogenase FadE5
IPR020953
Domain description: Acyl-CoA dehydrogenase, N-terminal, bacteria
Occurring in:
  1. Broad-specificity linear acyl-CoA dehydrogenase FadE5