Assemblies
Assembly Name:
Gamma-secretase complex, APH1A-PSEN1 variant
Multimeric state:
hetero tetramer
Accessible surface area:
61292.66 Å2
Buried surface area:
19729.48 Å2
Dissociation area:
1,666.21
Å2
Dissociation energy (ΔGdiss):
17.57
kcal/mol
Dissociation entropy (TΔSdiss):
12.76
kcal/mol
Symmetry number:
1
PDBe Complex ID:
PDB-CPX-156020
Macromolecules
Chain: A
Length: 709 amino acids
Theoretical weight: 78.48 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
UniProt:
Pfam:
InterPro:
Length: 709 amino acids
Theoretical weight: 78.48 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
UniProt:
- Canonical: Q92542 (Residues: 1-709; Coverage: 100%)
Pfam:
InterPro:
Chain: B
Length: 467 amino acids
Theoretical weight: 52.71 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
UniProt:
Pfam: Presenilin
InterPro:
Length: 467 amino acids
Theoretical weight: 52.71 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
UniProt:
- Canonical: P49768 (Residues: 1-467; Coverage: 100%)
Pfam: Presenilin
InterPro:
Chain: C
Length: 265 amino acids
Theoretical weight: 29.02 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
UniProt:
Pfam: Aph-1 protein
InterPro: Gamma-secretase subunit Aph-1
Length: 265 amino acids
Theoretical weight: 29.02 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
UniProt:
- Canonical: Q96BI3 (Residues: 1-265; Coverage: 100%)
Pfam: Aph-1 protein
InterPro: Gamma-secretase subunit Aph-1
Chain: D
Length: 143 amino acids
Theoretical weight: 16.5 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
UniProt:
Pfam: Presenilin enhancer-2 subunit of gamma secretase
InterPro: Gamma-secretase aspartyl protease complex, presenilin enhancer-2 subunit
Length: 143 amino acids
Theoretical weight: 16.5 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
UniProt:
- Canonical: Q9NZ42 (Residues: 2-101; Coverage: 99%)
Pfam: Presenilin enhancer-2 subunit of gamma secretase
InterPro: Gamma-secretase aspartyl protease complex, presenilin enhancer-2 subunit