› 6lw1

Electron Microscopy
2.8Å resolution

Cryo-EM structure of TLR7/Cpd-7 (DSR-139970) complex in open form

Released:
DOI: 10.2210/pdb6lw1/pdb
PDB entry 6lw1 coloured by chain, front view.
PDB entry 6lw1 coloured by chain, side view.
PDB entry 6lw1 coloured by chain, top view.
Source organism: Macaca mulatta
Primary publication:
Structural analysis reveals TLR7 dynamics underlying antagonism.
Tojo S, Zhang Z, Matsui H, Tahara M, Ikeguchi M, Kochi M, Kamada M, Shigematsu H, Tsutsumi A, Adachi N, Shibata T, Yamamoto M, Kikkawa M, Senda T, Isobe Y, Ohto U, Shimizu T
OpenAccess logo Nat Commun 11 5204 (2020)
PMID: 33060576
Related structures: EMD-30002

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-109967 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
TIR domain-containing protein Chains: A, B
Molecule details ›
Chains: A, B
Length: 823 amino acids
Theoretical weight: 94.75 KDa
Source organism: Macaca mulatta
Expression system: Drosophila melanogaster
UniProt:
  • Canonical: B3Y653 (Residues: 27-839; Coverage: 78%)
Gene name: TLR7
Sequence domains: Leucine rich repeat

Ligands and Environments

1 bound ligand:
Ligand EX3 2 x EX3
No modified residues

Experiments and Validation Details

Entry percentile scores
Resolution: 2.8Å
Relevant EMDB volumes: EMD-30002
Expression system: Drosophila melanogaster

Quick links

Citations

7 review citations

From influenza to COVID-19: Lipid nanoparticle mRNA vaccines at the frontiers of infectious diseases.
Pilkington et al. (2021)
6 more

6 mentions without citation

Structural and functional understanding of the toll-like receptors.
Asami et al. (2021)
5 more