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Crystal structure of human NEIL1(R242, Y244R) bound to duplex DNA containing 2'-fluoro-2'-deoxy-5,6-dihydrouridine

Source organisms:
Biochemical function: DNA N-glycosylase activity
Biological process: base-excision repair
Cellular component: not assigned

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EC 4.2.99.18: DNA-(apurinic or apyrimidinic site) lyase

Reaction catalysed:
The C-O-P bond 3' to the apurinic or apyrimidinic site in DNA is broken by a beta-elimination reaction, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
Systematic name:
DNA-(apurinic or apyrimidinic site) 5'-phosphomonoester-lyase
Alternative Name(s):
  • AP endonuclease class I
  • AP lyase
  • AP site-DNA 5'-phosphomonoester-lyase
  • Deoxyribonuclease (apurinic or apyrimidinic)
  • E. coli endonuclease III
  • E.coli endonuclease III
  • Endodeoxyribonuclease (apurinic or apyrimidinic)
  • Micrococcus luteus UV endonuclease
  • Phage-T(4) UV endonuclease
  • Phage-T4 UV endonuclease
  • X-ray endonuclease III

GO terms

Sequence families

Pfam Protein families (Pfam)
PF09292
Domain description: Endonuclease VIII-like 1, DNA bind
Occurring in:
  1. Endonuclease 8-like 1
The deposited structure of PDB entry 6lwp contains 3 copies of Pfam domain PF09292 (Endonuclease VIII-like 1, DNA bind) in Endonuclease 8-like 1. Showing 1 copy in chain A.

PF01149
Domain description: Formamidopyrimidine-DNA glycosylase N-terminal domain
Occurring in:
  1. Endonuclease 8-like 1
The deposited structure of PDB entry 6lwp contains 3 copies of Pfam domain PF01149 (Formamidopyrimidine-DNA glycosylase N-terminal domain) in Endonuclease 8-like 1. Showing 1 copy in chain A.

InterPro InterPro annotations
IPR012319
Domain description: Formamidopyrimidine-DNA glycosylase, catalytic domain
Occurring in:
  1. Endonuclease 8-like 1
IPR035937
Domain description: MutM-like, N-terminal
Occurring in:
  1. Endonuclease 8-like 1
IPR015371
Domain description: Endonuclease VIII-like 1, DNA binding
Occurring in:
  1. Endonuclease 8-like 1
IPR015886
Domain description: DNA glycosylase/AP lyase, H2TH DNA-binding
Occurring in:
  1. Endonuclease 8-like 1
IPR010979
Domain description: Small ribosomal subunit protein uS13-like, H2TH
Occurring in:
  1. Endonuclease 8-like 1

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