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Crystal structure of Streptococcus pyogenes endo-beta-N-acetylglucosaminidase (EndoS2) with high-mannose glycan

Source organism: Streptococcus pyogenes
Biochemical function: metal ion binding
Biological process: evasion of host immune response
Cellular component: host extracellular space

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EC 3.2.1.96: Mannosyl-glycoprotein endo-beta-N-acetylglucosaminidase

Reaction catalysed:
Endohydrolysis of the N,N'-diacetylchitobiosyl unit in high-mannose glycopeptides and glycoproteins containing the -(Man(GlcNAc)(2))Asn- structure. One N-acetyl-D-glucosamine residue remains attached to the protein, the rest of the oligosaccharide is released intact.
Systematic name:
Glycopeptide-D-mannosyl-N(4)-(N-acetyl-D-glucosaminyl)(2)-asparagine 1,4-N-acetyl-beta-glucosaminohydrolase
Alternative Name(s):
  • Di-N-acetylchitobiosyl beta-N-acetylglucosaminidase
  • Endo-N-acetyl-beta-D-glucosaminidase
  • Endo-N-acetyl-beta-glucosaminidase
  • Endo-beta-(1->4)-N-acetylglucosaminidase
  • Endo-beta-N-acetylglucosaminidase
  • Endo-beta-N-acetylglucosaminidase D
  • Endo-beta-N-acetylglucosaminidase F
  • Endo-beta-N-acetylglucosaminidase H
  • Endo-beta-N-acetylglucosaminidase L
  • Endo-beta-acetylglucosaminidase
  • Endoglycosidase H
  • Endoglycosidase S
  • Glycopeptide-D-mannosyl-4-N-(N-acetyl-D-glucosaminyl)(2)-asparagine 1,4-N-acetyl-beta-glucosaminohydrolase
  • Mannosyl-glycoprotein 1,4-N-acetamidodeoxy-beta-D-glycohydrolase
  • Mannosyl-glycoprotein endo-beta-N-acetylglucosamidase
  • N,N'-diacetylchitobiosyl beta-N-acetylglucosaminidase

GO terms

Sequence family

Pfam Protein family (Pfam)
PF20746
Domain description: Endo-beta-N-acetylglucosaminidase F2, Ig-like domain
Occurring in:
  1. Endo-beta-N-acetylglucosaminidase EndoS2
The deposited structure of PDB entry 6mdv contains 2 copies of Pfam domain PF20746 (Ig-like domain in endo-beta-N-acetylglucosaminidase F2) in Endo-beta-N-acetylglucosaminidase EndoS2. Showing 1 copy in chain A.

InterPro InterPro annotations
IPR032675
Domain description: Leucine-rich repeat domain superfamily
Occurring in:
  1. Endo-beta-N-acetylglucosaminidase EndoS2
IPR001579
Domain description: Glycosyl hydrolase family 18, active site
Occurring in:
  1. Endo-beta-N-acetylglucosaminidase EndoS2
IPR017853
Domain description: Glycoside hydrolase superfamily
Occurring in:
  1. Endo-beta-N-acetylglucosaminidase EndoS2

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