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H7 HA0 in complex with Fv from H7.5 IgG

Electron Microscopy
3.5Å resolution
PDB entry 6mlm coloured by chain, front view.
PDB entry 6mlm coloured by chain, side view.
PDB entry 6mlm coloured by chain, top view.
Source organisms:
Assembly composition:
hetero dodecamer (preferred)
Entry contents: 4 distinct polypeptide molecules

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Assemblies

Assembly 1 (preferred)
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Assembly Name: Hemagglutinin and IG-heavy chain and IG-light kappa chain
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Multimeric state: hetero dodecamer
Accessible surface area: 88569.73 Å2
Buried surface area: 40341.83 Å2
Dissociation area: 3,531.99 Å2
Dissociation energy (ΔGdiss): -5.54 kcal/mol
Dissociation entropy (TΔSdiss): 41.51 kcal/mol
Symmetry number: 3
PDBe Complex ID: PDB-CPX-207643

Macromolecules

Hemagglutinin
Chains: A, B, H
Length: 328 amino acids
Theoretical weight: 36.02 KDa
Source organism: Influenza A virus (A/New York/107/2003(H7N2))
Expression system: Homo sapiens
UniProt:
  • Canonical: B2LVD7 (Residues: 1-328; Coverage: 59%)
Gene name: HA
Pfam: Haemagglutinin
InterPro:
CATH:
Hemagglutinin in PDB entry 6mlm, assembly 1, front view.
Hemagglutinin in PDB entry 6mlm, assembly 1, side view.
Hemagglutinin in PDB entry 6mlm, assembly 1, top view.
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Hemagglutinin
Chains: C, D, J
Length: 224 amino acids
Theoretical weight: 25.58 KDa
Source organism: Influenza A virus (A/New York/107/2003(H7N2))
Expression system: Homo sapiens
UniProt:
  • Canonical: B2LVD7 (Residues: 329-552; Coverage: 41%)
Gene name: HA
Pfam: Haemagglutinin
InterPro:
CATH: Hemagglutinin Ectodomain; Chain B
Hemagglutinin in PDB entry 6mlm, assembly 1, front view.
Hemagglutinin in PDB entry 6mlm, assembly 1, side view.
Hemagglutinin in PDB entry 6mlm, assembly 1, top view.
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Heavy chain Fv of H7.5 Fab
Chains: E, F, K
Length: 219 amino acids
Theoretical weight: 23.44 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
InterPro:
Heavy chain Fv of H7.5 Fab in PDB entry 6mlm, assembly 1, front view.
Heavy chain Fv of H7.5 Fab in PDB entry 6mlm, assembly 1, side view.
Heavy chain Fv of H7.5 Fab in PDB entry 6mlm, assembly 1, top view.
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Light chain Fv of H7.5 Fab
Chains: G, I, L
Length: 213 amino acids
Theoretical weight: 23.34 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
InterPro:
Light chain Fv of H7.5 Fab in PDB entry 6mlm, assembly 1, front view.
Light chain Fv of H7.5 Fab in PDB entry 6mlm, assembly 1, side view.
Light chain Fv of H7.5 Fab in PDB entry 6mlm, assembly 1, top view.
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