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Structure of full-length IP3R1 channel bound with Adenophostin A

Electron Microscopy
4.1Å resolution
PDB entry 6mu1 coloured by chain, front view.
PDB entry 6mu1 coloured by chain, side view.
PDB entry 6mu1 coloured by chain, top view.
Source organism: Rattus norvegicus
Assembly composition:
homo tetramer (preferred)
Entry contents: 1 distinct polypeptide molecule

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Assemblies

Assembly 1 (preferred)
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Assembly Name: Inositol 1,4,5-trisphosphate-gated calcium channel ITPR1
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Multimeric state: homo tetramer
Accessible surface area: 472257.56 Å2
Buried surface area: 26361.29 Å2
Dissociation area: 13,180.65 Å2
Dissociation energy (ΔGdiss): 105.08 kcal/mol
Dissociation entropy (TΔSdiss): 57.96 kcal/mol
Symmetry number: 4
PDBe Complex ID: PDB-CPX-151603

Macromolecules

Inositol 1,4,5-trisphosphate-gated calcium channel ITPR1
Chains: A, B, C, D
Length: 2739 amino acids
Theoretical weight: 312.44 KDa
Source organism: Rattus norvegicus
UniProt:
  • Canonical: P29994 (Residues: 1-2739; Coverage: 100%)
Gene names: Insp3r, Itpr1
Pfam:
InterPro:
Inositol 1,4,5-trisphosphate receptor type 1 in PDB entry 6mu1, assembly 1, front view.
Inositol 1,4,5-trisphosphate receptor type 1 in PDB entry 6mu1, assembly 1, side view.
Inositol 1,4,5-trisphosphate receptor type 1 in PDB entry 6mu1, assembly 1, top view.
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