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The structure of the Plasmodium falciparum 20S proteasome.

Source organism: Plasmodium falciparum 3D7
Biochemical function: hydrolase activity
Biological process: proteolysis involved in protein catabolic process
Cellular component: proteasome core complex

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EC 3.4.25.1: Proteasome endopeptidase complex

Reaction catalysed:
Cleavage of peptide bonds with very broad specificity.
Alternative Name(s):
  • 26S protease
  • Alkaline protease
  • Ingensin
  • Large multicatalytic protease
  • Lens neutral proteinase
  • MCP
  • Macropain
  • Multicatalytic endopeptidase complex
  • Multicatalytic proteinase
  • Multicatalytic proteinase (complex)
  • Prosome
  • Proteasome
  • Proteasome organelle
  • Tricorn protease
  • Tricorn proteinase

GO terms

Biochemical function:
Biological process:
Cellular component:

Sequence families

Pfam Protein families (Pfam)
PF00227
Domain description: Proteasome subunit
Occurring in:
  1. Proteasome alpha-type subunits domain-containing protein
  2. Proteasome alpha-type subunits domain-containing protein
  3. Proteasome subunit alpha type
  4. Proteasome subunit alpha type
  5. Proteasome subunit alpha type
  6. Proteasome alpha-type subunits domain-containing protein
  7. Proteasome alpha-type subunits domain-containing protein
  8. Proteasome subunit beta type-6, putative
  9. Proteasome subunit beta
  10. Proteasome subunit beta
  11. Proteasome subunit beta
  12. Proteasome subunit beta
  13. Proteasome subunit beta
The deposited structure of PDB entry 6muw contains 2 copies of Pfam domain PF00227 (Proteasome subunit) in Proteasome alpha-type subunits domain-containing protein. Showing 1 copy in chain A.
The deposited structure of PDB entry 6muw contains 2 copies of Pfam domain PF00227 (Proteasome subunit) in Proteasome alpha-type subunits domain-containing protein. Showing 1 copy in chain W [auth P].
The deposited structure of PDB entry 6muw contains 2 copies of Pfam domain PF00227 (Proteasome subunit) in Proteasome subunit alpha type. Showing 1 copy in chain AA [auth Q].
The deposited structure of PDB entry 6muw contains 2 copies of Pfam domain PF00227 (Proteasome subunit) in Proteasome subunit alpha type. Showing 1 copy in chain S [auth R].
The deposited structure of PDB entry 6muw contains 2 copies of Pfam domain PF00227 (Proteasome subunit) in Proteasome subunit alpha type. Showing 1 copy in chain O [auth S].
The deposited structure of PDB entry 6muw contains 2 copies of Pfam domain PF00227 (Proteasome subunit) in Proteasome alpha-type subunits domain-containing protein. Showing 1 copy in chain T.
The deposited structure of PDB entry 6muw contains 2 copies of Pfam domain PF00227 (Proteasome subunit) in Proteasome alpha-type subunits domain-containing protein. Showing 1 copy in chain BA [auth U].
The deposited structure of PDB entry 6muw contains 4 copies of Pfam domain PF00227 (Proteasome subunit) in Proteasome subunit beta type-6, putative. Showing 2 copies in chain Z [auth V].
The deposited structure of PDB entry 6muw contains 2 copies of Pfam domain PF00227 (Proteasome subunit) in Proteasome subunit beta. Showing 1 copy in chain I.
The deposited structure of PDB entry 6muw contains 2 copies of Pfam domain PF00227 (Proteasome subunit) in Proteasome subunit beta. Showing 1 copy in chain J.
The deposited structure of PDB entry 6muw contains 2 copies of Pfam domain PF00227 (Proteasome subunit) in Proteasome subunit beta. Showing 1 copy in chain K.
The deposited structure of PDB entry 6muw contains 2 copies of Pfam domain PF00227 (Proteasome subunit) in Proteasome subunit beta. Showing 1 copy in chain L.
The deposited structure of PDB entry 6muw contains 4 copies of Pfam domain PF00227 (Proteasome subunit) in Proteasome subunit beta. Showing 2 copies in chain N.

PF10584
Domain description: Proteasome subunit A N-terminal signature
Occurring in:
  1. Proteasome alpha-type subunits domain-containing protein
  2. Proteasome alpha-type subunits domain-containing protein
  3. Proteasome subunit alpha type
  4. Proteasome subunit alpha type
  5. Proteasome subunit alpha type
  6. Proteasome alpha-type subunits domain-containing protein
  7. Proteasome alpha-type subunits domain-containing protein
The deposited structure of PDB entry 6muw contains 2 copies of Pfam domain PF10584 (Proteasome subunit A N-terminal signature) in Proteasome alpha-type subunits domain-containing protein. Showing 1 copy in chain A.
The deposited structure of PDB entry 6muw contains 2 copies of Pfam domain PF10584 (Proteasome subunit A N-terminal signature) in Proteasome alpha-type subunits domain-containing protein. Showing 1 copy in chain B.
The deposited structure of PDB entry 6muw contains 2 copies of Pfam domain PF10584 (Proteasome subunit A N-terminal signature) in Proteasome subunit alpha type. Showing 1 copy in chain AA [auth Q].
The deposited structure of PDB entry 6muw contains 2 copies of Pfam domain PF10584 (Proteasome subunit A N-terminal signature) in Proteasome subunit alpha type. Showing 1 copy in chain S [auth R].
The deposited structure of PDB entry 6muw contains 2 copies of Pfam domain PF10584 (Proteasome subunit A N-terminal signature) in Proteasome subunit alpha type. Showing 1 copy in chain O [auth S].
The deposited structure of PDB entry 6muw contains 2 copies of Pfam domain PF10584 (Proteasome subunit A N-terminal signature) in Proteasome alpha-type subunits domain-containing protein. Showing 1 copy in chain T.
The deposited structure of PDB entry 6muw contains 2 copies of Pfam domain PF10584 (Proteasome subunit A N-terminal signature) in Proteasome alpha-type subunits domain-containing protein. Showing 1 copy in chain BA [auth U].

InterPro InterPro annotations
IPR029055
Domain description: Nucleophile aminohydrolases, N-terminal
Occurring in:
  1. Proteasome alpha-type subunits domain-containing protein
  2. Proteasome alpha-type subunits domain-containing protein
  3. Proteasome subunit alpha type
  4. Proteasome subunit alpha type
  5. Proteasome subunit alpha type
  6. Proteasome alpha-type subunits domain-containing protein
  7. Proteasome alpha-type subunits domain-containing protein
  8. Proteasome subunit beta type-6, putative
  9. Proteasome subunit beta
  10. Proteasome subunit beta
  11. Proteasome subunit beta
  12. Proteasome subunit beta
  13. 20S proteasome beta-6 subunit
  14. Proteasome subunit beta
IPR001353
Domain description: Proteasome, subunit alpha/beta
Occurring in:
  1. Proteasome alpha-type subunits domain-containing protein
  2. Proteasome alpha-type subunits domain-containing protein
  3. Proteasome subunit alpha type
  4. Proteasome subunit alpha type
  5. Proteasome subunit alpha type
  6. Proteasome alpha-type subunits domain-containing protein
  7. Proteasome alpha-type subunits domain-containing protein
  8. Proteasome subunit beta type-6, putative
  9. Proteasome subunit beta
  10. Proteasome subunit beta
  11. Proteasome subunit beta
  12. Proteasome subunit beta
  13. 20S proteasome beta-6 subunit
  14. Proteasome subunit beta
IPR023333
Domain description: Proteasome B-type subunit
Occurring in:
  1. Proteasome subunit beta type-6, putative
  2. Proteasome subunit beta
  3. Proteasome subunit beta
  4. Proteasome subunit beta
  5. 20S proteasome beta-6 subunit
  6. Proteasome subunit beta
IPR000426
Domain description: Proteasome alpha-subunit, N-terminal domain
Occurring in:
  1. Proteasome alpha-type subunits domain-containing protein
  2. Proteasome alpha-type subunits domain-containing protein
  3. Proteasome subunit alpha type
  4. Proteasome subunit alpha type
  5. Proteasome subunit alpha type
  6. Proteasome alpha-type subunits domain-containing protein
  7. Proteasome alpha-type subunits domain-containing protein
IPR000243
Domain description: Peptidase T1A, proteasome beta-subunit
Occurring in:
  1. Proteasome subunit beta
  2. Proteasome subunit beta
IPR016050
Domain description: Proteasome beta-type subunit, conserved site
Occurring in:
  1. Proteasome subunit beta
  2. Proteasome subunit beta
  3. Proteasome subunit beta
  4. Proteasome subunit beta
  5. 20S proteasome beta-6 subunit
  6. Proteasome subunit beta
IPR023332
Domain description: Proteasome alpha-type subunit
Occurring in:
  1. Proteasome alpha-type subunits domain-containing protein
  2. Proteasome alpha-type subunits domain-containing protein
  3. Proteasome subunit alpha type
  4. Proteasome subunit alpha type
  5. Proteasome subunit alpha type
  6. Proteasome alpha-type subunits domain-containing protein
IPR016295
Domain description: Proteasome subunit beta 4
Occurring in:
  1. Proteasome subunit beta
IPR035206
Domain description: Proteasome subunit beta 2
Occurring in:
  1. Proteasome subunit beta
IPR033811
Domain description: Proteasome beta 3 subunit
Occurring in:
  1. Proteasome subunit beta
IPR035144
Domain description: Proteasome subunit alpha 1
Occurring in:
  1. Proteasome alpha-type subunits domain-containing protein
IPR033812
Domain description: Proteasome subunit alpha5
Occurring in:
  1. Proteasome subunit alpha type
IPR034642
Domain description: Proteasome subunit alpha6
Occurring in:
  1. Proteasome alpha-type subunits domain-containing protein

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