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The structure of the Plasmodium falciparum 20S proteasome.

Electron Microscopy
3.6Å resolution
PDB entry 6muw coloured by chain, front view.
PDB entry 6muw coloured by chain, side view.
PDB entry 6muw coloured by chain, top view.
Source organism: Plasmodium falciparum 3D7
Assembly composition:
hetero 28-mer (preferred)
Entry contents: 14 distinct polypeptide molecules

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Assemblies

Assembly 1 (preferred)
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Assembly Name: Proteasome core complex
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Multimeric state: hetero 28-mer
Accessible surface area: 216871.6 Å2
Buried surface area: 116596.68 Å2
Dissociation area: 6,819.36 Å2
Dissociation energy (ΔGdiss): 45.31 kcal/mol
Dissociation entropy (TΔSdiss): 28.68 kcal/mol
Symmetry number: 2
PDBe Complex ID: PDB-CPX-111606

Macromolecules

Proteasome alpha-type subunits domain-containing protein
Chains: A, O
Length: 260 amino acids
Theoretical weight: 29.53 KDa
Source organism: Plasmodium falciparum 3D7
UniProt:
  • Canonical: Q8IAR3 (Residues: 1-260; Coverage: 100%)
Gene name: PF3D7_0807500
Pfam:
InterPro:
Proteasome alpha-type subunits domain-containing protein in PDB entry 6muw, assembly 1, front view.
Proteasome alpha-type subunits domain-containing protein in PDB entry 6muw, assembly 1, side view.
Proteasome alpha-type subunits domain-containing protein in PDB entry 6muw, assembly 1, top view.
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Proteasome alpha-type subunits domain-containing protein
Chains: B, P
Length: 235 amino acids
Theoretical weight: 26.56 KDa
Source organism: Plasmodium falciparum 3D7
UniProt:
  • Canonical: C6KST3 (Residues: 1-235; Coverage: 100%)
Gene name: PF3D7_0608500
Pfam:
InterPro:
Proteasome alpha-type subunits domain-containing protein in PDB entry 6muw, assembly 1, front view.
Proteasome alpha-type subunits domain-containing protein in PDB entry 6muw, assembly 1, side view.
Proteasome alpha-type subunits domain-containing protein in PDB entry 6muw, assembly 1, top view.
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Proteasome subunit alpha type
Chains: C, Q
Length: 246 amino acids
Theoretical weight: 27.98 KDa
Source organism: Plasmodium falciparum 3D7
UniProt:
  • Canonical: Q8IDG3 (Residues: 1-246; Coverage: 100%)
Gene name: PF3D7_1353800
Pfam:
InterPro:
Proteasome subunit alpha type in PDB entry 6muw, assembly 1, front view.
Proteasome subunit alpha type in PDB entry 6muw, assembly 1, side view.
Proteasome subunit alpha type in PDB entry 6muw, assembly 1, top view.
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Proteasome subunit alpha type
Chains: D, R
Length: 241 amino acids
Theoretical weight: 27.26 KDa
Source organism: Plasmodium falciparum 3D7
UniProt:
  • Canonical: Q8IDG2 (Residues: 1-241; Coverage: 100%)
Gene name: PF3D7_1353900
Pfam:
InterPro:
Proteasome subunit alpha type in PDB entry 6muw, assembly 1, front view.
Proteasome subunit alpha type in PDB entry 6muw, assembly 1, side view.
Proteasome subunit alpha type in PDB entry 6muw, assembly 1, top view.
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Proteasome subunit alpha type
Chains: E, S
Length: 256 amino acids
Theoretical weight: 28.42 KDa
Source organism: Plasmodium falciparum 3D7
UniProt:
  • Canonical: Q8IBI3 (Residues: 1-256; Coverage: 100%)
Gene name: PF3D7_0727400
Pfam:
InterPro:
Proteasome subunit alpha type in PDB entry 6muw, assembly 1, front view.
Proteasome subunit alpha type in PDB entry 6muw, assembly 1, side view.
Proteasome subunit alpha type in PDB entry 6muw, assembly 1, top view.
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Proteasome alpha-type subunits domain-containing protein
Chains: F, T
Length: 254 amino acids
Theoretical weight: 28.87 KDa
Source organism: Plasmodium falciparum 3D7
UniProt:
  • Canonical: Q8IK90 (Residues: 1-254; Coverage: 100%)
Gene name: PF3D7_1474800
Pfam:
InterPro:
Proteasome alpha-type subunits domain-containing protein in PDB entry 6muw, assembly 1, front view.
Proteasome alpha-type subunits domain-containing protein in PDB entry 6muw, assembly 1, side view.
Proteasome alpha-type subunits domain-containing protein in PDB entry 6muw, assembly 1, top view.
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Proteasome alpha-type subunits domain-containing protein
Chains: G, U
Length: 252 amino acids
Theoretical weight: 29.32 KDa
Source organism: Plasmodium falciparum 3D7
UniProt:
  • Canonical: O77396 (Residues: 1-252; Coverage: 100%)
Gene name: PF3D7_0317000
Pfam:
InterPro:
Proteasome alpha-type subunits domain-containing protein in PDB entry 6muw, assembly 1, front view.
Proteasome alpha-type subunits domain-containing protein in PDB entry 6muw, assembly 1, side view.
Proteasome alpha-type subunits domain-containing protein in PDB entry 6muw, assembly 1, top view.
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Proteasome subunit beta type-6, putative
Chains: H, V
Length: 252 amino acids
Theoretical weight: 29.14 KDa
Source organism: Plasmodium falciparum 3D7
UniProt:
  • Canonical: Q8I0U7 (Residues: 31-282; Coverage: 89%)
Gene name: PF3D7_0931800
Pfam: Proteasome subunit
InterPro:
Proteasome subunit beta type-6, putative in PDB entry 6muw, assembly 1, front view.
Proteasome subunit beta type-6, putative in PDB entry 6muw, assembly 1, side view.
Proteasome subunit beta type-6, putative in PDB entry 6muw, assembly 1, top view.
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Proteasome subunit beta
Chains: I, W
Length: 229 amino acids
Theoretical weight: 25.1 KDa
Source organism: Plasmodium falciparum 3D7
UniProt:
  • Canonical: Q8I6T3 (Residues: 42-270; Coverage: 85%)
Gene name: PF3D7_1328100
Pfam: Proteasome subunit
InterPro:
Proteasome subunit beta in PDB entry 6muw, assembly 1, front view.
Proteasome subunit beta in PDB entry 6muw, assembly 1, side view.
Proteasome subunit beta in PDB entry 6muw, assembly 1, top view.
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Proteasome subunit beta
Chains: J, X
Length: 218 amino acids
Theoretical weight: 24.53 KDa
Source organism: Plasmodium falciparum 3D7
UniProt:
  • Canonical: Q8I261 (Residues: 1-218; Coverage: 100%)
Gene name: PF3D7_0108000
Pfam: Proteasome subunit
InterPro:
Proteasome subunit beta in PDB entry 6muw, assembly 1, front view.
Proteasome subunit beta in PDB entry 6muw, assembly 1, side view.
Proteasome subunit beta in PDB entry 6muw, assembly 1, top view.
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Proteasome subunit beta
Chains: K, Y
Length: 195 amino acids
Theoretical weight: 22.89 KDa
Source organism: Plasmodium falciparum 3D7
UniProt:
  • Canonical: Q8IKC9 (Residues: 1-195; Coverage: 100%)
Gene name: PF3D7_1470900
Pfam: Proteasome subunit
InterPro:
Proteasome subunit beta in PDB entry 6muw, assembly 1, front view.
Proteasome subunit beta in PDB entry 6muw, assembly 1, side view.
Proteasome subunit beta in PDB entry 6muw, assembly 1, top view.
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Proteasome subunit beta
Chains: L, Z
Length: 211 amino acids
Theoretical weight: 23.62 KDa
Source organism: Plasmodium falciparum 3D7
UniProt:
  • Canonical: Q8IJT1 (Residues: 61-271; Coverage: 78%)
Gene name: PF3D7_1011400
Pfam: Proteasome subunit
InterPro:
Proteasome subunit beta in PDB entry 6muw, assembly 1, front view.
Proteasome subunit beta in PDB entry 6muw, assembly 1, side view.
Proteasome subunit beta in PDB entry 6muw, assembly 1, top view.
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20S proteasome beta-6 subunit
Chains: M, a
Length: 240 amino acids
Theoretical weight: 27.3 KDa
Source organism: Plasmodium falciparum 3D7
InterPro:
20S proteasome beta-6 subunit in PDB entry 6muw, assembly 1, front view.
20S proteasome beta-6 subunit in PDB entry 6muw, assembly 1, side view.
20S proteasome beta-6 subunit in PDB entry 6muw, assembly 1, top view.
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Proteasome subunit beta
Chains: N, b
Length: 265 amino acids
Theoretical weight: 30.91 KDa
Source organism: Plasmodium falciparum 3D7
UniProt:
  • Canonical: Q7K6A9 (Residues: 1-265; Coverage: 100%)
Gene name: PF3D7_0803800
Pfam: Proteasome subunit
InterPro:
Proteasome subunit beta in PDB entry 6muw, assembly 1, front view.
Proteasome subunit beta in PDB entry 6muw, assembly 1, side view.
Proteasome subunit beta in PDB entry 6muw, assembly 1, top view.
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