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Crystal structure of the dimeric bH1-Fab variant [HC-Y33W,HC-D98M,HC-G99M,LC-S30bR]

X-ray diffraction
1.69Å resolution
PDB entry 6my4 coloured by chain, front view.
PDB entry 6my4 coloured by chain, side view.
PDB entry 6my4 coloured by chain, top view.
Source organism: Homo sapiens
Assembly composition:
hetero tetramer (preferred)
Entry contents: 2 distinct polypeptide molecules

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Assemblies

Assembly 1 (preferred)
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Assembly Name: IG-light kappa chain and IG-heavy chain
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Multimeric state: hetero tetramer
Accessible surface area: 36818.66 Å2
Buried surface area: 12178.06 Å2
Dissociation area: 1,565.58 Å2
Dissociation energy (ΔGdiss): 11.98 kcal/mol
Dissociation entropy (TΔSdiss): 14.43 kcal/mol
Symmetry number: 2
PDBe Complex ID: PDB-CPX-182258

Macromolecules

Ig-like domain-containing protein
Chains: A, H
Length: 236 amino acids
Theoretical weight: 25.42 KDa
Source organism: Homo sapiens
Expression system: Cricetulus griseus
UniProt:
  • Canonical: V9HW68 (Residues: 20-246; Coverage: 50%)
Gene name: HEL-214
Pfam:
InterPro:
Ig-like domain-containing protein in PDB entry 6my4, assembly 1, front view.
Ig-like domain-containing protein in PDB entry 6my4, assembly 1, side view.
Ig-like domain-containing protein in PDB entry 6my4, assembly 1, top view.
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Ig-like domain-containing protein
Chains: B, L
Length: 218 amino acids
Theoretical weight: 24.03 KDa
Source organism: Homo sapiens
Expression system: Cricetulus griseus
UniProt:
  • Canonical: Q7Z3Y4 (Residues: 23-51, 52-236; Coverage: 100%)
Pfam:
InterPro:
Ig-like domain-containing protein in PDB entry 6my4, assembly 1, front view.
Ig-like domain-containing protein in PDB entry 6my4, assembly 1, side view.
Ig-like domain-containing protein in PDB entry 6my4, assembly 1, top view.
Molecule details ›

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