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Crystal structure of fms kinase domain with a small molecular inhibitor, PLX5622

X-ray diffraction
2.25Å resolution
PDB entry 6n33 coloured by chain, front view.
PDB entry 6n33 coloured by chain, side view.
PDB entry 6n33 coloured by chain, top view.
Source organism: Homo sapiens
Assembly composition:
monomeric (preferred)
Entry contents: 1 distinct polypeptide molecule

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Assemblies

Assembly 1 (preferred)
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Assembly Name: Macrophage colony-stimulating factor 1 receptor
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Multimeric state: monomeric
Accessible surface area: 14028.55 Å2
Buried surface area: 0.0 Å2
Dissociation area: 0 Å2
Dissociation energy (ΔGdiss): 0 kcal/mol
Dissociation entropy (TΔSdiss): 0 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-139513

Macromolecules

Macrophage colony-stimulating factor 1 receptor
Chain: A
Length: 343 amino acids
Theoretical weight: 38.64 KDa
Source organism: Homo sapiens
Expression system: Spodoptera frugiperda
UniProt:
  • Canonical: P07333 (Residues: 542-919; Coverage: 35%)
Gene names: CSF1R, FMS
Pfam: Protein tyrosine and serine/threonine kinase
InterPro:
Macrophage colony-stimulating factor 1 receptor in PDB entry 6n33, assembly 1, front view.
Macrophage colony-stimulating factor 1 receptor in PDB entry 6n33, assembly 1, side view.
Macrophage colony-stimulating factor 1 receptor in PDB entry 6n33, assembly 1, top view.
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