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Horse liver alcohol dehydrogenase determined using single-particle cryo-EM at 200 keV

Source organism: Equus caballus
Biochemical function: metal ion binding
Biological process: retinoic acid metabolic process
Cellular component: cytosol

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EC 1.1.1.1: Alcohol dehydrogenase

Reaction catalysed:
A primary alcohol + NAD(+) = an aldehyde + NADH
Systematic name:
Alcohol:NAD(+) oxidoreductase
Alternative Name(s):
  • ADH
  • Alcohol dehydrogenase (NAD)
  • Aldehyde reductase
  • Aliphatic alcohol dehydrogenase
  • Ethanol dehydrogenase
  • NAD-dependent alcohol dehydrogenase
  • NAD-specific aromatic alcohol dehydrogenase
  • NADH-alcohol dehydrogenase
  • NADH-aldehyde dehydrogenase
  • Primary alcohol dehydrogenase
  • Yeast alcohol dehydrogenase

GO terms

Sequence families

Pfam Protein families (Pfam)
PF00107
Domain description: Zinc-binding dehydrogenase
Occurring in:
  1. Alcohol dehydrogenase E chain
The deposited structure of PDB entry 6nbb contains 2 copies of Pfam domain PF00107 (Zinc-binding dehydrogenase) in Alcohol dehydrogenase E chain. Showing 1 copy in chain A.

PF08240
Domain description: Alcohol dehydrogenase GroES-like domain
Occurring in:
  1. Alcohol dehydrogenase E chain
The deposited structure of PDB entry 6nbb contains 2 copies of Pfam domain PF08240 (Alcohol dehydrogenase GroES-like domain) in Alcohol dehydrogenase E chain. Showing 1 copy in chain A.

InterPro InterPro annotations
IPR011032
Domain description: GroES-like superfamily
Occurring in:
  1. Alcohol dehydrogenase E chain
IPR013149
Domain description: Alcohol dehydrogenase-like, C-terminal
Occurring in:
  1. Alcohol dehydrogenase E chain
IPR036291
Domain description: NAD(P)-binding domain superfamily
Occurring in:
  1. Alcohol dehydrogenase E chain
IPR002328
Domain description: Alcohol dehydrogenase, zinc-type, conserved site
Occurring in:
  1. Alcohol dehydrogenase E chain
IPR013154
Domain description: Alcohol dehydrogenase-like, N-terminal
Occurring in:
  1. Alcohol dehydrogenase E chain
IPR020843
Domain description: Polyketide synthase, enoylreductase domain
Occurring in:
  1. Alcohol dehydrogenase E chain

Structure domains

CATH CATH domains
3.90.180.10
Class: Alpha Beta
Architecture: Alpha-Beta Complex
Topology: Quinone Oxidoreductase; Chain A, domain 1
Homology: Medium-chain alcohol dehydrogenases, catalytic domain
Occurring in:
  1. Alcohol dehydrogenase E chain
The deposited structure of PDB entry 6nbb contains 2 copies of CATH domain 3.90.180.10 (Quinone Oxidoreductase; Chain A, domain 1) in Alcohol dehydrogenase E chain. Showing 1 copy in chain A.
3.40.50.720
Class: Alpha Beta
Architecture: 3-Layer(aba) Sandwich
Topology: Rossmann fold
Homology: NAD(P)-binding Rossmann-like Domain
Occurring in:
  1. Alcohol dehydrogenase E chain
The deposited structure of PDB entry 6nbb contains 2 copies of CATH domain 3.40.50.720 (Rossmann fold) in Alcohol dehydrogenase E chain. Showing 1 copy in chain A.

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