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Cryo-EM structure of vaccine-elicited antibody 0PV-c.01 in complex with HIV-1 Env BG505 DS-SOSIP and antibodies VRC03 and PGT122

Source organisms:
Biochemical function: structural molecule activity
Biological process: not assigned
Cellular component: viral envelope

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GO terms

Biochemical function:
Biological process:
  • not assigned
Cellular component:

Sequence families

Pfam Protein families (Pfam)
PF00516
Domain description: Envelope glycoprotein GP120
Occurring in:
  1. Transmembrane protein gp41
The deposited structure of PDB entry 6nf2 contains 6 copies of Pfam domain PF00516 (Envelope glycoprotein GP120) in Transmembrane protein gp41. Showing 2 copies in chain A.

PF00517
Domain description: Retroviral envelope protein
Occurring in:
  1. Transmembrane protein gp41
The deposited structure of PDB entry 6nf2 contains 3 copies of Pfam domain PF00517 (Retroviral envelope protein) in Transmembrane protein gp41. Showing 1 copy in chain B.

InterPro InterPro annotations
IPR003597
Domain description: Immunoglobulin C1-set
Occurring in:
  1. VRC03 Heavy Chain
  2. VRC03 Light Chain
  3. PGT122 Heavy Chain
  4. PGT122 Light Chain
  5. 0PV-c.01 Heavy Chain
  6. 0PV-c.01 Light Chain
IPR036179
Domain description: Immunoglobulin-like domain superfamily
Occurring in:
  1. VRC03 Heavy Chain
  2. VRC03 Light Chain
  3. PGT122 Heavy Chain
  4. PGT122 Light Chain
  5. 0PV-c.01 Heavy Chain
  6. 0PV-c.01 Light Chain
IPR013783
Domain description: Immunoglobulin-like fold
Occurring in:
  1. VRC03 Heavy Chain
  2. VRC03 Light Chain
  3. PGT122 Heavy Chain
  4. PGT122 Light Chain
  5. 0PV-c.01 Heavy Chain
  6. 0PV-c.01 Light Chain
IPR007110
Domain description: Immunoglobulin-like domain
Occurring in:
  1. VRC03 Heavy Chain
  2. VRC03 Light Chain
  3. PGT122 Heavy Chain
  4. PGT122 Light Chain
  5. 0PV-c.01 Heavy Chain
  6. 0PV-c.01 Light Chain
IPR013106
Domain description: Immunoglobulin V-set domain
Occurring in:
  1. VRC03 Heavy Chain
  2. VRC03 Light Chain
  3. PGT122 Heavy Chain
  4. PGT122 Light Chain
  5. 0PV-c.01 Heavy Chain
  6. 0PV-c.01 Light Chain
IPR003599
Domain description: Immunoglobulin domain subtype
Occurring in:
  1. VRC03 Heavy Chain
  2. VRC03 Light Chain
  3. PGT122 Heavy Chain
  4. PGT122 Light Chain
  5. 0PV-c.01 Heavy Chain
  6. 0PV-c.01 Light Chain
IPR003006
Domain description: Immunoglobulin/major histocompatibility complex, conserved site
Occurring in:
  1. VRC03 Heavy Chain
  2. VRC03 Light Chain
  3. PGT122 Heavy Chain
  4. PGT122 Light Chain
  5. 0PV-c.01 Heavy Chain
  6. 0PV-c.01 Light Chain
IPR036377
Domain description: Gp120 core superfamily
Occurring in:
  1. Transmembrane protein gp41
IPR000328
Domain description: Retroviral envelope protein GP41-like
Occurring in:
  1. Transmembrane protein gp41
IPR000777
Domain description: Human immunodeficiency virus 1, envelope glycoprotein Gp120
Occurring in:
  1. Transmembrane protein gp41

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