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Structure of the KcsA-G77C mutant or the 2,4-ion bound configuration of a K+ channel selectivity filter.

X-ray diffraction
2.13Å resolution
PDB entry 6nfv coloured by chain, front view.
PDB entry 6nfv coloured by chain, side view.
PDB entry 6nfv coloured by chain, top view.
Source organisms:
Assembly composition:
hetero dodecamer (preferred)
Entry contents: 3 distinct polypeptide molecules

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Assemblies

Assembly 1 (preferred)
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Assembly Name: pH-gated potassium channel KcsA and IG-heavy chain and IG-light kappa chain
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Multimeric state: hetero dodecamer
Accessible surface area: 86400.79 Å2
Buried surface area: 37099.76 Å2
Dissociation area: 469.98 Å2
Dissociation energy (ΔGdiss): -2.47 kcal/mol
Dissociation entropy (TΔSdiss): 4.1 kcal/mol
Symmetry number: 4
PDBe Complex ID: PDB-CPX-209490

Macromolecules

antibody fragment heavy chain
Chain: A
Length: 219 amino acids
Theoretical weight: 23.41 KDa
Source organism: Mus musculus
Expression system: Mammalia
InterPro:
antibody fragment heavy chain in PDB entry 6nfv, assembly 1, front view.
antibody fragment heavy chain in PDB entry 6nfv, assembly 1, side view.
antibody fragment heavy chain in PDB entry 6nfv, assembly 1, top view.
121920406080100120140160180200
 
100200
Chains
RSRZ Outlier Chain A (auth A)
Chain A (auth A)
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antibody fragment light chain
Chain: B
Length: 212 amino acids
Theoretical weight: 23.44 KDa
Source organism: Mus musculus
Expression system: Mammalia
InterPro:
antibody fragment light chain in PDB entry 6nfv, assembly 1, front view.
antibody fragment light chain in PDB entry 6nfv, assembly 1, side view.
antibody fragment light chain in PDB entry 6nfv, assembly 1, top view.
121220406080100120140160180200
 
50100150200
Chains
RSRZ Outlier Chain B (auth B)
Chain B (auth B)
Domains
Secondary structure
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pH-gated potassium channel KcsA
Chain: C
Length: 103 amino acids
Theoretical weight: 11.02 KDa
Source organism: Streptomyces lividans
Expression system: Escherichia coli
UniProt:
  • Canonical: P0A334 (Residues: 22-124; Coverage: 64%)
Gene names: kcsA, skc1
Pfam:
InterPro: Potassium channel domain
pH-gated potassium channel KcsA in PDB entry 6nfv, assembly 1, front view.
pH-gated potassium channel KcsA in PDB entry 6nfv, assembly 1, side view.
pH-gated potassium channel KcsA in PDB entry 6nfv, assembly 1, top view.
PDBe-KB: UniProt Coverage View: P0A334  
1103102030405060708090100
 
50100SALHWRAAGAATVLLVIVLLAGSYLAVLAERGAPGAQLITYPRALWWSVETATTVCYGDLYPVTLWGRCVAVVVMVAGITSFGLVTAALATWFVGREQERRGH
UniProt
P0A334
Chains
Domains
Secondary structure
Flexibility predictions
Ligand binding sites
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