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C-abl Kinase domain with the activator(cmpd29), N-(1-(3,4-dichlorophenyl)-4,5-dihydro-1H-pyrazol-3-yl)acetamide

X-ray diffraction
2.33Å resolution
PDB entry 6npu coloured by chain, front view.
PDB entry 6npu coloured by chain, side view.
PDB entry 6npu coloured by chain, top view.
Source organism: Homo sapiens
Assembly composition:
homo dimer (preferred)
Entry contents: 1 distinct polypeptide molecule

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Assemblies

Assembly 1 (preferred)
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Assembly Name: Tyrosine-protein kinase ABL1
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Multimeric state: homo dimer
Accessible surface area: 24489.61 Å2
Buried surface area: 5126.67 Å2
Dissociation area: 997.85 Å2
Dissociation energy (ΔGdiss): 4.57 kcal/mol
Dissociation entropy (TΔSdiss): 12.95 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-132620

Macromolecules

Tyrosine-protein kinase ABL1
Chains: A, B
Length: 298 amino acids
Theoretical weight: 34.71 KDa
Source organism: Homo sapiens
Expression system: Spodoptera aff. frugiperda 2 RZ-2014
UniProt:
  • Canonical: P00519 (Residues: 229-512; Coverage: 25%)
Gene names: ABL, ABL1, JTK7
Pfam: Protein tyrosine and serine/threonine kinase
InterPro:
CATH:
Tyrosine-protein kinase ABL1 in PDB entry 6npu, assembly 1, front view.
Tyrosine-protein kinase ABL1 in PDB entry 6npu, assembly 1, side view.
Tyrosine-protein kinase ABL1 in PDB entry 6npu, assembly 1, top view.
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