› 6nt5

Electron Microscopy
4.1Å resolution

Cryo-EM structure of full-length human STING in the apo state

Released:
DOI: 10.2210/pdb6nt5/pdb
PDB entry 6nt5 coloured by chain, front view.
PDB entry 6nt5 coloured by chain, side view.
PDB entry 6nt5 coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Cryo-EM structures of STING reveal its mechanism of activation by cyclic GMP-AMP.
Shang G, Zhang C, Chen ZJ, Bai XC, Zhang X
Nature 567 389-393 (2019)
PMID: 30842659
Related structures: EMD-0502

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-183240 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Stimulator of interferon genes protein Chains: A, B
Molecule details ›
Chains: A, B
Length: 385 amino acids
Theoretical weight: 42.99 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
UniProt:
  • Canonical: Q86WV6 (Residues: 1-379; Coverage: 100%)
Gene names: ERIS, MITA, STING, STING1, TMEM173
Sequence domains: Transmembrane protein 173

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
Resolution: 4.1Å
Relevant EMDB volumes: EMD-0502
Expression system: Homo sapiens

Quick links

Citations

99 review citations

Molecular mechanisms and cellular functions of cGAS-STING signalling.
Hopfner et al. (2020)
98 more

25 mentions without citation

The cGAS-STING pathway as a therapeutic target in inflammatory diseases.
Decout et al. (2021)
24 more