GO terms
Biochemical function:
- DNA-binding transcription factor binding
- protein serine/threonine kinase binding
- RNA polymerase II-specific DNA-binding transcription factor binding
- 2',3'-cyclic GMP-AMP binding
- protein homodimerization activity
- identical protein binding
- signaling adaptor activity
- cyclic-di-GMP binding
- ubiquitin protein ligase binding
- protein kinase binding
- proton channel activity
- protein binding
- nucleotide binding
Biological process:
- proton transmembrane transport
- cGAS/STING signaling pathway
- antiviral innate immune response
- cellular response to exogenous dsRNA
- protein localization to endoplasmic reticulum
- reticulophagy
- positive regulation of type I interferon-mediated signaling pathway
- defense response to virus
- protein complex oligomerization
- positive regulation of DNA-binding transcription factor activity
- regulation of inflammatory response
- positive regulation of transcription by RNA polymerase II
- innate immune response
- cellular response to interferon-beta
- monoatomic ion transmembrane transport
- positive regulation of interferon-beta production
- positive regulation of type I interferon production
- regulation of metabolic process
- positive regulation of macroautophagy
- regulation of gene expression
- autophagy
- monoatomic ion transport
- cytoplasmic pattern recognition receptor signaling pathway
- immune system process
- positive regulation of defense response to virus by host
- pattern recognition receptor signaling pathway
- activation of innate immune response
- autophagosome assembly
Cellular component:
- STING complex
- serine/threonine protein kinase complex
- perinuclear region of cytoplasm
- ciliary basal body
- endoplasmic reticulum-Golgi intermediate compartment membrane
- cytoplasmic vesicle
- secretory granule membrane
- cytoplasmic vesicle membrane
- membrane
- cilium
- plasma membrane
- cytosol
- Golgi apparatus
- endoplasmic reticulum membrane
- endoplasmic reticulum
- peroxisome
- autophagosome
- endosome
- mitochondrial outer membrane
- mitochondrion
- cytoplasm
- nucleoplasm
- autophagosome membrane
- Golgi membrane
Sequence family
Protein family (Pfam)
InterPro annotations
IPR038623
Domain description:
Stimulator of interferon genes protein, C-terminal domain superfamily
Occurring in:
Occurring in:
IPR033952
Domain description:
Stimulator of interferon genes protein homolog, C-terminal
Occurring in:
Occurring in: