Structure analysis

Structure of drug-resistant V27A mutant of the influenza M2 proton channel bound to spiroadamantyl amine inhibitor

X-ray diffraction
2.5Å resolution
Assembly composition:
homo tetramer (preferred)
Entry contents: 1 distinct polypeptide molecule

Assemblies

Assembly 1 (preferred)
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Multimeric state: homo tetramer
Accessible surface area: 6237.13 Å2
Buried surface area: 4798.43 Å2
Dissociation area: 2,169.84 Å2
Dissociation energy (ΔGdiss): 29.27 kcal/mol
Dissociation entropy (TΔSdiss): 25.61 kcal/mol
Symmetry number: 4
PDBe Complex ID: PDB-CPX-107264
Assembly 2
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Multimeric state: homo tetramer
Accessible surface area: 6814.39 Å2
Buried surface area: 5083.58 Å2
Dissociation area: 2,314.56 Å2
Dissociation energy (ΔGdiss): 29.66 kcal/mol
Dissociation entropy (TΔSdiss): 26.18 kcal/mol
Symmetry number: 4
PDBe Complex ID: PDB-CPX-107264

Macromolecules

Chains: A, B, C, D, E, F, G, H
Length: 27 amino acids
Theoretical weight: 2.73 KDa
Source organism: Influenza A virus (A/Indonesia/CDC1031RE2/2007(H5N1))
Expression system: Not provided
UniProt:
  • Canonical: A4D7H3 (Residues: 22-46; Coverage: 26%)
Gene names: M, M2
InterPro: Influenza virus matrix protein 2
PDBe-KB: UniProt Coverage View: A4D7H3  
1272468101214161820222426
 
1020*SSDPLAVAASIIGILHLILWILDRL*
UniProt
A4D7H3
Chains
Domains
Secondary structure
Flexibility predictions
Ligand binding sites
Interaction interfaces
Sequence conservation

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