Structure analysis

Brutons tyrosine kinase in complex with compound 50.

X-ray diffraction
1.72Å resolution
Source organism: Homo sapiens
Assembly composition:
monomeric (preferred)
Entry contents: 1 distinct polypeptide molecule

Assemblies

Assembly 1 (preferred)
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Multimeric state: monomeric
Accessible surface area: 12818.22 Å2
Buried surface area: 62.87 Å2
Dissociation area: 31.43 Å2
Dissociation energy (ΔGdiss): -0.16 kcal/mol
Dissociation entropy (TΔSdiss): -0.31 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-170299
Assembly 2
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Multimeric state: monomeric
Accessible surface area: 12746.96 Å2
Buried surface area: 106.5 Å2
Dissociation area: 53.25 Å2
Dissociation energy (ΔGdiss): -0.54 kcal/mol
Dissociation entropy (TΔSdiss): -0.34 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-170299

Macromolecules

Chains: A, D
Length: 280 amino acids
Theoretical weight: 32.41 KDa
Source organism: Homo sapiens
Expression system: Spodoptera frugiperda
UniProt:
  • Canonical: Q06187 (Residues: 382-659; Coverage: 42%)
Gene names: AGMX1, ATK, BPK, BTK
Pfam: Protein tyrosine and serine/threonine kinase
InterPro:

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