› 6nzm

X-ray diffraction
1.72Å resolution

Function and Biology Details

Reaction catalysed: 
ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate
Biochemical function:
Biological process:
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-170299 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Tyrosine-protein kinase BTK Chains: A, D
Molecule details ›
Chains: A, D
Length: 280 amino acids
Theoretical weight: 32.41 KDa
Source organism: Homo sapiens
Expression system: Spodoptera frugiperda
UniProt:
  • Canonical: Q06187 (Residues: 382-659; Coverage: 42%)
Gene names: AGMX1, ATK, BPK, BTK
Sequence domains: Protein tyrosine and serine/threonine kinase

Ligands and Environments

2 bound ligands:
Ligand L9S 2 x L9S
Ligand EDO 2 x EDO
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 31-ID
Spacegroup: P21
Unit cell:
a: 38.297Å b: 71.709Å c: 104.41Å
α: 90° β: 89.95° γ: 90°
R-values:
R R work R free
0.179 0.176 0.248
Expression system: Spodoptera frugiperda

Quick links

Citations

2 review citations

Application of Fragment-Based Drug Discovery to Versatile Targets.
Li Q. (2020)
1 more

1 mention without citation

In-silico probing of AML related RUNX1 cancer-associated missense mutations: Predicted relationships to DNA binding and drug interactions.
Ullah et al. (2022)