› › Structure analysis

PQR530 [(S)-4-(Difluoromethyl)-5-(4-(3-methylmorpholino)-6-morpholino-1,3,5-triazin-2-yl)pyridin-2-amine] bound to the PI3Ka catalytic subunit p110alpha

X-ray diffraction
3.15Å resolution
PDB entry 6oac coloured by chain, front view.
PDB entry 6oac coloured by chain, side view.
PDB entry 6oac coloured by chain, top view.
Source organism: Homo sapiens
Assembly composition:
monomeric (preferred)
Entry contents: 1 distinct polypeptide molecule

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Assemblies

Assembly 1 (preferred)
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Assembly Name: Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform
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Multimeric state: monomeric
Accessible surface area: 35833.4 Å2
Buried surface area: 0.0 Å2
Dissociation area: 0 Å2
Dissociation energy (ΔGdiss): 0 kcal/mol
Dissociation entropy (TΔSdiss): 0 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-154615

Macromolecules

Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform
Chain: A
Length: 948 amino acids
Theoretical weight: 110.2 KDa
Source organism: Homo sapiens
Expression system: Spodoptera frugiperda
UniProt:
  • Canonical: P42336 (Residues: 105-1048; Coverage: 88%)
Gene name: PIK3CA
Pfam:
InterPro:
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform in PDB entry 6oac, assembly 1, front view.
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform in PDB entry 6oac, assembly 1, side view.
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform in PDB entry 6oac, assembly 1, top view.
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