› 6oiz

Electron crystallography
1.1Å resolution

Amyloid-Beta (20-34) wild type

Released:
DOI: 10.2210/pdb6oiz/pdb
PDB entry 6oiz coloured by chain, front view.
PDB entry 6oiz coloured by chain, side view.
PDB entry 6oiz coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Structure of amyloid-β (20-34) with Alzheimer's-associated isomerization at Asp23 reveals a distinct protofilament interface.
Warmack RA, Boyer DR, Zee CT, Richards LS, Sawaya MR, Cascio D, Gonen T, Eisenberg DS, Clarke SG
OpenAccess logo Nat Commun 10 3357 (2019)
PMID: 31350392
Related structures: EMD-20082

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
homo pentamer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-529016 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
P3(40) Chain: A
Molecule details ›
Chain: A
Length: 15 amino acids
Theoretical weight: 1.49 KDa
Source organism: Homo sapiens
Expression system: Not provided
UniProt:
  • Canonical: P05067 (Residues: 691-705; Coverage: 2%)
Gene names: A4, AD1, APP
Sequence domains: Beta-amyloid peptide (beta-APP)

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
Resolution: 1.1Å
Relevant EMDB volumes: EMD-20082
Expression system: Not provided

Quick links

Citations

6 review citations

Molecular Damage in Aging.
Gladyshev et al. (2021)
5 more

2 mentions without citation

Electron Diffraction of 3D Molecular Crystals.
Saha et al. (2022)
1 more