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In situ structure of rotavirus VP1 RNA-dependent RNA polymerase (DLP_RNA)

Source organism: Simian rotavirus A strain RRV
Biochemical function: RNA binding
Biological process: viral genome replication
Cellular component: viral inner capsid

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EC 2.7.7.48: RNA-directed RNA polymerase

Reaction catalysed:
Nucleoside triphosphate + RNA(n) = diphosphate + RNA(n+1)
Systematic name:
Nucleoside-triphosphate:RNA nucleotidyltransferase (RNA-directed)
Alternative Name(s):
  • 3D polymerase
  • PB1 proteins
  • PB2 proteins
  • Phage f2 replicase
  • Polymerase L
  • Q-beta replicase
  • RDRP
  • RNA nucleotidyltransferase (RNA-directed)
  • RNA replicase
  • RNA synthetase
  • RNA transcriptase
  • RNA-dependent RNA polymerase
  • RNA-dependent RNA replicase
  • RNA-dependent ribonucleate nucleotidyltransferase
  • Ribonucleic acid replicase
  • Ribonucleic acid-dependent ribonucleate nucleotidyltransferase
  • Ribonucleic acid-dependent ribonucleic acid polymerase
  • Ribonucleic replicase
  • Ribonucleic synthetase
  • Transcriptase

GO terms

Sequence families

Pfam Protein families (Pfam)
PF05087
Domain description: Rotavirus VP2 protein
Occurring in:
  1. Inner capsid protein VP2
The deposited structure of PDB entry 6oj6 contains 10 copies of Pfam domain PF05087 (Rotavirus VP2 protein) in Inner capsid protein VP2. Showing 1 copy in chain D.

PF12289
Domain description: Rotavirus VP1 C-terminal domain
Occurring in:
  1. RNA-directed RNA polymerase
The deposited structure of PDB entry 6oj6 contains 1 copy of Pfam domain PF12289 (Rotavirus VP1 C-terminal domain) in RNA-directed RNA polymerase. Showing 1 copy in chain K [auth P].

PF02123
Domain description: Viral RNA-directed RNA-polymerase
Occurring in:
  1. RNA-directed RNA polymerase
The deposited structure of PDB entry 6oj6 contains 1 copy of Pfam domain PF02123 (Viral RNA-directed RNA-polymerase) in RNA-directed RNA polymerase. Showing 1 copy in chain K [auth P].

InterPro InterPro annotations
IPR007779
Domain description: Rotavirus VP2
Occurring in:
  1. Inner capsid protein VP2
IPR022071
Domain description: Rotavirus VP1 RNA-directed RNA polymerase, C-terminal
Occurring in:
  1. RNA-directed RNA polymerase
IPR007097
Domain description: RNA-directed RNA polymerase, reovirus
Occurring in:
  1. RNA-directed RNA polymerase
IPR043502
Domain description: DNA/RNA polymerase superfamily
Occurring in:
  1. RNA-directed RNA polymerase
IPR042032
Domain description: Viral RNA-directed RNA polymerase, 4-helical domain
Occurring in:
  1. RNA-directed RNA polymerase
IPR001795
Domain description: RNA-directed RNA polymerase, luteovirus
Occurring in:
  1. RNA-directed RNA polymerase

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