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Crosslinked Crystal Structure of Type II Fatty Acid Synthase Ketosynthase, FabB, and C16-crypto Acyl Carrier Protein, AcpP

Source organism: Escherichia coli K-12
Biochemical function: phosphopantetheine binding
Biological process: fatty acid biosynthetic process
Cellular component: cytosol

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EC 2.3.1.41: Beta-ketoacyl-[acyl-carrier-protein] synthase I

Reaction catalysed:
Acyl-[acyl-carrier-protein] + malonyl-[acyl-carrier-protein] = 3-oxoacyl-[acyl-carrier-protein] + CO(2) + [acyl-carrier-protein]
Systematic name:
Acyl-[acyl-carrier protein]:malonyl-[acyl-carrier protein] C-acyltransferase (decarboxylating)
Alternative Name(s):
  • 3-ketoacyl-acyl carrier protein synthase
  • 3-oxoacyl-[acyl-carrier-protein] synthase
  • 3-oxoacyl:ACP synthase I
  • Acyl-[acyl-carrier-protein]:malonyl-[acyl-carrier-protein] C-acyltransferase (decarboxylating)
  • Acyl-malonyl acyl carrier protein-condensing enzyme
  • Acyl-malonyl(acyl-carrier-protein)-condensing enzyme
  • Beta-ketoacyl acyl carrier protein synthase
  • Beta-ketoacyl synthetase
  • Beta-ketoacyl-ACP synthase I
  • Beta-ketoacyl-ACP synthetase
  • Beta-ketoacyl-[acyl carrier protein] synthase
  • Beta-ketoacyl-acyl carrier protein synthetase
  • Beta-ketoacylsynthase
  • Condensing enzyme
  • FabB
  • FabF1
  • Fatty acid condensing enzyme
  • KAS I
  • KASI

GO terms

Sequence families

Pfam Protein families (Pfam)
PF00550
Domain description: Phosphopantetheine attachment site
Occurring in:
  1. Acyl carrier protein
The deposited structure of PDB entry 6okf contains 2 copies of Pfam domain PF00550 (Phosphopantetheine attachment site) in Acyl carrier protein. Showing 1 copy in chain C.

PF02801
Domain description: Beta-ketoacyl synthase, C-terminal domain
Occurring in:
  1. 3-oxoacyl-[acyl-carrier-protein] synthase 1
The deposited structure of PDB entry 6okf contains 2 copies of Pfam domain PF02801 (Beta-ketoacyl synthase, C-terminal domain) in 3-oxoacyl-[acyl-carrier-protein] synthase 1. Showing 1 copy in chain A.

PF00109
Domain description: Beta-ketoacyl synthase, N-terminal domain
Occurring in:
  1. 3-oxoacyl-[acyl-carrier-protein] synthase 1
The deposited structure of PDB entry 6okf contains 2 copies of Pfam domain PF00109 (Beta-ketoacyl synthase, N-terminal domain) in 3-oxoacyl-[acyl-carrier-protein] synthase 1. Showing 1 copy in chain A.

InterPro InterPro annotations
IPR016039
Domain description: Thiolase-like
Occurring in:
  1. 3-oxoacyl-[acyl-carrier-protein] synthase 1
IPR003231
Domain description: Acyl carrier protein
Occurring in:
  1. Acyl carrier protein
IPR009081
Domain description: Phosphopantetheine binding ACP domain
Occurring in:
  1. Acyl carrier protein
IPR036736
Domain description: ACP-like superfamily
Occurring in:
  1. Acyl carrier protein
IPR000794
Domain description: Beta-ketoacyl synthase
Occurring in:
  1. 3-oxoacyl-[acyl-carrier-protein] synthase 1
IPR020841
Domain description: Polyketide synthase, beta-ketoacyl synthase domain
Occurring in:
  1. 3-oxoacyl-[acyl-carrier-protein] synthase 1
IPR006162
Domain description: Phosphopantetheine attachment site
Occurring in:
  1. Acyl carrier protein
IPR014031
Domain description: Beta-ketoacyl synthase, C-terminal
Occurring in:
  1. 3-oxoacyl-[acyl-carrier-protein] synthase 1
IPR018201
Domain description: Beta-ketoacyl synthase, active site
Occurring in:
  1. 3-oxoacyl-[acyl-carrier-protein] synthase 1
IPR014030
Domain description: Beta-ketoacyl synthase-like, N-terminal
Occurring in:
  1. 3-oxoacyl-[acyl-carrier-protein] synthase 1

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