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B41 SOSIP.664 in complex with the silent-face antibody SF12 and V3-targeting antibody 10-1074

Electron Microscopy
3.28Å resolution
PDB entry 6okp coloured by chain, front view.
PDB entry 6okp coloured by chain, side view.
PDB entry 6okp coloured by chain, top view.
Source organisms:
Assembly composition:
hetero tetradecamer (preferred)
Entry contents: 6 distinct polypeptide molecules

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Assemblies

Assembly 1 (preferred)
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Multimeric state: hetero tetradecamer
Accessible surface area: 137689.48 Å2
Buried surface area: 75995.28 Å2
Dissociation area: 8,522.14 Å2
Dissociation energy (ΔGdiss): -118.94 kcal/mol
Dissociation entropy (TΔSdiss): 98.4 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-109935

Macromolecules

Transmembrane protein gp41
Chains: A, B, C
Length: 153 amino acids
Theoretical weight: 17.36 KDa
Source organism: Human immunodeficiency virus 1
Expression system: Cricetulus griseus
UniProt:
  • Canonical: B3UEZ6 (Residues: 516-668; Coverage: 18%)
Gene name: env
Pfam: Retroviral envelope protein
InterPro: Retroviral envelope protein GP41-like
Transmembrane protein gp41 in PDB entry 6okp, assembly 1, front view.
Transmembrane protein gp41 in PDB entry 6okp, assembly 1, side view.
Transmembrane protein gp41 in PDB entry 6okp, assembly 1, top view.
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Envelope glycoprotein gp160
Chains: D, E, F
Length: 516 amino acids
Theoretical weight: 57.7 KDa
Source organism: Human immunodeficiency virus 1
Expression system: Cricetulus griseus
UniProt:
  • Canonical: B3UES2 (Residues: 29-509; Coverage: 56%)
Gene name: env
Pfam: Envelope glycoprotein GP120
InterPro:
Envelope glycoprotein gp160 in PDB entry 6okp, assembly 1, front view.
Envelope glycoprotein gp160 in PDB entry 6okp, assembly 1, side view.
Envelope glycoprotein gp160 in PDB entry 6okp, assembly 1, top view.
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Ig-like domain-containing protein
Chain: K
Length: 244 amino acids
Theoretical weight: 26.49 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
UniProt:
  • Canonical: S6B291 (Residues: 20-117, 118-123, 124-243; Coverage: 50%)
Pfam:
InterPro:
Ig-like domain-containing protein in PDB entry 6okp, assembly 1, front view.
Ig-like domain-containing protein in PDB entry 6okp, assembly 1, side view.
Ig-like domain-containing protein in PDB entry 6okp, assembly 1, top view.
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Ig-like domain-containing protein
Chain: L
Length: 214 amino acids
Theoretical weight: 23.18 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
UniProt:
  • Canonical: Q8N5F4 (Residues: 29-85, 86-111, 112-233; Coverage: 96%)
Gene name: IGL@
Pfam:
InterPro:
Ig-like domain-containing protein in PDB entry 6okp, assembly 1, front view.
Ig-like domain-containing protein in PDB entry 6okp, assembly 1, side view.
Ig-like domain-containing protein in PDB entry 6okp, assembly 1, top view.
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Ig-like domain-containing protein
Chains: M, O, Q
Length: 241 amino acids
Theoretical weight: 26.05 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
UniProt:
  • Canonical: S6B291 (Residues: 20-117, 118-118, 119-125, 126-243; Coverage: 50%)
Pfam:
InterPro:
Ig-like domain-containing protein in PDB entry 6okp, assembly 1, front view.
Ig-like domain-containing protein in PDB entry 6okp, assembly 1, side view.
Ig-like domain-containing protein in PDB entry 6okp, assembly 1, top view.
Molecule details ›

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Immunoglobulin kappa constant
Chains: N, P, R
Length: 212 amino acids
Theoretical weight: 23.24 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
UniProt:
  • Canonical: P01834 (Residues: 1-107; Coverage: 100%)
Gene name: IGKC
Pfam: Immunoglobulin C1-set domain
InterPro:
Immunoglobulin kappa constant in PDB entry 6okp, assembly 1, front view.
Immunoglobulin kappa constant in PDB entry 6okp, assembly 1, side view.
Immunoglobulin kappa constant in PDB entry 6okp, assembly 1, top view.
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