6oni

X-ray diffraction
1.8Å resolution

Crystal structure of PPARgamma ligand binding domain in complex with N-CoR peptide and inverse agonist T0070907

Released:

Function and Biology Details

Structure analysis Details

Assembly composition:
hetero dimer (preferred)
PDBe Complex ID:
PDB-CPX-130926 (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
Peroxisome proliferator-activated receptor gamma Chain: B
Molecule details ›
Chain: B
Length: 275 amino acids
Theoretical weight: 31.45 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: P37231 (Residues: 231-505; Coverage: 55%)
Gene names: NR1C3, PPARG
Sequence domains: Ligand-binding domain of nuclear hormone receptor
Nuclear receptor corepressor 1 Chain: D
Molecule details ›
Chain: D
Length: 23 amino acids
Theoretical weight: 2.51 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: O75376 (Residues: 2256-2278; Coverage: 1%)
Gene names: KIAA1047, NCOR1

Ligands and Environments

1 bound ligand:
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: SSRL BEAMLINE BL12-2
Spacegroup: P41212
Unit cell:
a: 61.876Å b: 61.876Å c: 164.379Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.209 0.208 0.226
Expression system: Escherichia coli BL21(DE3)