Structure analysis

Crystal structure of PPARgamma ligand binding domain in complex with N-CoR peptide and inverse agonist T0070907

X-ray diffraction
1.8Å resolution
Source organism: Homo sapiens
Assembly composition:
hetero dimer (preferred)
Entry contents: 2 distinct polypeptide molecules

Assemblies

Assembly 1 (preferred)
Download    3D Visualisation
Multimeric state: hetero dimer
Accessible surface area: 14158.76 Å2
Buried surface area: 1053.32 Å2
Dissociation area: 526.66 Å2
Dissociation energy (ΔGdiss): 1.33 kcal/mol
Dissociation entropy (TΔSdiss): 7.61 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-130926

Macromolecules

Chain: B
Length: 275 amino acids
Theoretical weight: 31.45 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: P37231 (Residues: 231-505; Coverage: 55%)
Gene names: NR1C3, PPARG
Pfam: Ligand-binding domain of nuclear hormone receptor
InterPro:

Search similar proteins

Chain: D
Length: 23 amino acids
Theoretical weight: 2.51 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: O75376 (Residues: 2256-2278; Coverage: 1%)
Gene names: KIAA1047, NCOR1

Search similar proteins