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Modified BG505 SOSIP-based immunogen RC1 in complex with the elicited V3-glycan patch bNAb 10-1074

Electron Microscopy
4.05Å resolution
PDB entry 6orn coloured by chain, front view.
PDB entry 6orn coloured by chain, side view.
PDB entry 6orn coloured by chain, top view.
Source organisms:
Assembly composition:
hetero dodecamer (preferred)
Entry contents: 4 distinct polypeptide molecules

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Assemblies

Assembly 1 (preferred)
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Assembly Name: Envelope glycoprotein gp160 and IG-heavy chain and IG-light lambda chain
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Multimeric state: hetero dodecamer
Accessible surface area: 130982.73 Å2
Buried surface area: 55022.55 Å2
Dissociation area: 6,387.09 Å2
Dissociation energy (ΔGdiss): -10.94 kcal/mol
Dissociation entropy (TΔSdiss): 75.99 kcal/mol
Symmetry number: 3
PDBe Complex ID: PDB-CPX-212152

Macromolecules

Transmembrane protein gp41
Chains: C, J, Q
Length: 153 amino acids
Theoretical weight: 17.13 KDa
Source organism: Human immunodeficiency virus 1
Expression system: Homo sapiens
UniProt:
  • Canonical: Q2N0S6 (Residues: 509-661; Coverage: 18%)
Gene name: env
Pfam: Retroviral envelope protein
InterPro: Retroviral envelope protein GP41-like
Transmembrane protein gp41 in PDB entry 6orn, assembly 1, front view.
Transmembrane protein gp41 in PDB entry 6orn, assembly 1, side view.
Transmembrane protein gp41 in PDB entry 6orn, assembly 1, top view.
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Envelope glycoprotein gp160
Chains: G, K, R
Length: 481 amino acids
Theoretical weight: 54.15 KDa
Source organism: Human immunodeficiency virus 1
Expression system: Homo sapiens
UniProt:
  • Canonical: Q2N0S6 (Residues: 30-508; Coverage: 56%)
Gene name: env
Pfam: Envelope glycoprotein GP120
InterPro:
Envelope glycoprotein gp160 in PDB entry 6orn, assembly 1, front view.
Envelope glycoprotein gp160 in PDB entry 6orn, assembly 1, side view.
Envelope glycoprotein gp160 in PDB entry 6orn, assembly 1, top view.
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10-1074 antibody Fab heavy chain
Chains: A, F, O
Length: 238 amino acids
Theoretical weight: 25.66 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
InterPro:
10-1074 antibody Fab heavy chain in PDB entry 6orn, assembly 1, front view.
10-1074 antibody Fab heavy chain in PDB entry 6orn, assembly 1, side view.
10-1074 antibody Fab heavy chain in PDB entry 6orn, assembly 1, top view.
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10-1074 antibody Fab light chain
Chains: B, I, P
Length: 214 amino acids
Theoretical weight: 23.18 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
InterPro:
10-1074 antibody Fab light chain in PDB entry 6orn, assembly 1, front view.
10-1074 antibody Fab light chain in PDB entry 6orn, assembly 1, side view.
10-1074 antibody Fab light chain in PDB entry 6orn, assembly 1, top view.
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