› 6ows

Electron Microscopy
2.98Å resolution

Cryo-EM structure of an Acinetobacter baumannii multidrug efflux pump

Released:
DOI: 10.2210/pdb6ows/pdb
PDB entry 6ows coloured by chain, front view.
PDB entry 6ows coloured by chain, side view.
PDB entry 6ows coloured by chain, top view.
Source organism: Acinetobacter baumannii
Primary publication:
Cryo-Electron Microscopy Structure of an Acinetobacter baumannii Multidrug Efflux Pump.
Su CC, Morgan CE, Kambakam S, Rajavel M, Scott H, Huang W, Emerson CC, Taylor DJ, Stewart PL, Bonomo RA, Yu EW
OpenAccess logo mBio 10 (2019)
PMID: 31266873
Related structures: EMD-20216

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
homo trimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-173394 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Efflux pump membrane transporter Chains: A, B, C
Molecule details ›
Chains: A, B, C
Length: 1035 amino acids
Theoretical weight: 112.59 KDa
Source organism: Acinetobacter baumannii
Expression system: Escherichia coli
UniProt:
  • Canonical: Q2FD70 (Residues: 2-1036; Coverage: 100%)
Gene names: 32_436, EA686_00900, GNY86_15955, adeB
Sequence domains: AcrB/AcrD/AcrF family

Ligands and Environments

1 bound ligand:
Ligand PTY 6 x PTY
No modified residues

Experiments and Validation Details

Entry percentile scores
Resolution: 2.98Å
Relevant EMDB volumes: EMD-20216
Expression system: Escherichia coli

Quick links

Citations

7 review citations

Antimicrobial Resistance in ESKAPE Pathogens.
De Oliveira et al. (2020)
6 more

13 mentions without citation

Structural Insights into Transporter-Mediated Drug Resistance in Infectious Diseases.
Kim et al. (2021)
12 more