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Spastin hexamer in complex with substrate

Source organism: Drosophila melanogaster
Biochemical function: ATP hydrolysis activity
Biological process: not assigned
Cellular component: not assigned

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EC 5.6.1.1: Microtubule-severing ATPase

Reaction catalysed:
n ATP + n H(2)O + a microtubule = n ADP + n phosphate + (n+1) alpha/beta tubulin heterodimers
Systematic name:
ATP phosphohydrolase (tubulin-dimerizing)
Alternative Name(s):
  • Katanin

GO terms

Biochemical function:
Biological process:
  • not assigned
Cellular component:
  • not assigned

Sequence families

Pfam Protein families (Pfam)
PF09336
Domain description: Vps4 C terminal oligomerisation domain
Occurring in:
  1. Spastin
The deposited structure of PDB entry 6p07 contains 6 copies of Pfam domain PF09336 (Vps4 C terminal oligomerisation domain) in Spastin. Showing 1 copy in chain B.

PF17862
Domain description: AAA+ lid domain
Occurring in:
  1. Spastin
The deposited structure of PDB entry 6p07 contains 6 copies of Pfam domain PF17862 (AAA+ lid domain) in Spastin. Showing 1 copy in chain B.

PF00004
Domain description: ATPase family associated with various cellular activities (AAA)
Occurring in:
  1. Spastin
The deposited structure of PDB entry 6p07 contains 6 copies of Pfam domain PF00004 (ATPase family associated with various cellular activities (AAA)) in Spastin. Showing 1 copy in chain B.

InterPro InterPro annotations
IPR027417
Domain description: P-loop containing nucleoside triphosphate hydrolase
Occurring in:
  1. Spastin
IPR041569
Domain description: AAA ATPase, AAA+ lid domain
Occurring in:
  1. Spastin
IPR003960
Domain description: ATPase, AAA-type, conserved site
Occurring in:
  1. Spastin
IPR003959
Domain description: ATPase, AAA-type, core
Occurring in:
  1. Spastin
IPR003593
Domain description: AAA+ ATPase domain
Occurring in:
  1. Spastin
IPR007330
Domain description: MIT domain
Occurring in:
  1. Spastin
IPR036181
Domain description: MIT domain superfamily
Occurring in:
  1. Spastin
IPR017179
Domain description: Spastin
Occurring in:
  1. Spastin

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